ID T1KJP1_TETUR Unreviewed; 734 AA.
AC T1KJP1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=107364991 {ECO:0000313|EnsemblMetazoa:tetur13g00640.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur13g00640.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur13g00640.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CAEY01000163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015787935.1; XM_015932449.1.
DR AlphaFoldDB; T1KJP1; -.
DR STRING; 32264.T1KJP1; -.
DR EnsemblMetazoa; tetur13g00640.1; tetur13g00640.1; tetur13g00640.
DR GeneID; 107364991; -.
DR KEGG; tut:107364991; -.
DR eggNOG; KOG2464; Eukaryota.
DR HOGENOM; CLU_377822_0_0_1; -.
DR OrthoDB; 5491350at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035173; F:histone kinase activity; IEA:UniProt.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR024604; GSG2_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR24419; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; 1.
DR PANTHER; PTHR24419:SF18; SERINE_THREONINE-PROTEIN KINASE HASPIN; 1.
DR Pfam; PF12330; Haspin_kinase; 1.
DR SMART; SM01331; DUF3635; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 420..734
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 152..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 448
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 734 AA; 83331 MW; 41D7E583F55B4D47 CRC64;
METVKSPLKA NYCRLPVKSR AEKLFDQFVT KTTFADRSND LNLLSQDSPT NHKEVKTRLK
RKVTFATYAG DKQRKEVKKK TLVKRKEPTK CTKEAVLEAF MNAGLPDYDE IAALPLNIVV
LSDANKQPEK YTEISRKQIV KPFMPLLKKI DSASKRKESN PAINIEEPSC ADNEVSSDHI
EDRENKEEAS TPLPNAKARP KFDDISCINA NNTLDPNMDQ DVSFTTPKVP PPAKKKPWNV
ADRRGTQLLP PHPVVFDEPL VISNTSIDVS NDQPLNWSTV HSLAKMDDSV HNVFSIDTKA
NLATKIRESL GSLKSNMNEA EYPRGSVNFY RRSIVDTANV LRALGKSCRT IVREPSRRIT
RKRKESLAEN QTVNFLVAFD KTIIEDVDVH LPLTTKEKVL ALCNPPQITT FNNVLNHSLM
KSICKIGEGS YGEVFKSKTE DDKEVVIKVV PLVPTTSVED DLWAQVLPEL VISLTFSDLR
SGLRNQTPNF VNTFRASCVN GSWPKELVKA WNEYNKLKKS ENDHPDKYGP NCNWLIILLN
NGGIDLENHK FSSAVESLSV ILQTALSLAA AESEFEFEHR DLHTGNVLIM PCSESMLEYK
IDGKNIMLPS VGLKVSVIDF TLARMAKDGY TVYDDLSKYE DLFTGTGDYQ FEIYRLMRIA
NKNNWKVFTP YTNILWVHYL TYKLTKDKKY RSRSKAHHAA MKALKHLHNL LLDYKSTKQF
VQSPYFNELF SKLS
//
