ID T1KTC7_TETUR Unreviewed; 406 AA.
AC T1KTC7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur20g02740.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur20g02740.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR EMBL; CAEY01000522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1KTC7; -.
DR STRING; 32264.T1KTC7; -.
DR EnsemblMetazoa; tetur20g02740.1; tetur20g02740.1; tetur20g02740.
DR eggNOG; KOG3988; Eukaryota.
DR HOGENOM; CLU_046916_0_0_1; -.
DR OMA; LNDFRQC; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788:SF10; PROTEIN-TYROSINE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ SEQUENCE 406 AA; 45413 MW; 8AD6B6CC9601293A CRC64;
MYQYNVPTCL VSTSSNVLTS KNGPQQQQQG IGDSIPWSSS ANLLSASSLL SGSSDLTVTG
ISRSIPLIFI GGMPRSGTTL LRVILDAHPD VRCGEETRVI PRLLGYRAQW MKSPFESRRL
QEAGITPEVL DSAISAFILE VVGKHGPPAQ RLCNKDPFTL RSAVYLKKLF PNSKFIFMIR
DGRAVVHSII TRKVTISGFD LSDYRQCMTK WNSAMQAMHN QCETLGPSYC LPVYYEQMVL
KPELWLRKIL EFLDVPWNDS VLNHEKLIDK PGGISLSKLE RSTDQVIKPI NVEALSKWVG
HIPEDVVRDM ASVAPMLSVL GYDPAANPPD YGKPDAFVVN KMKDLSSNRK KWEEKEHELL
KVRQSIQSDI IKQRGSSKPS KEYLDNEIGQ SIGYRLTKEQ ASSKDS
//
