ID T1P846_MUSDO Unreviewed; 425 AA.
AC T1P846;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=DNA-binding protein {ECO:0000313|EMBL:AFP59450.1};
GN Name=101891116 {ECO:0000313|EnsemblMetazoa:MDOA012561-PA};
GN Synonyms=LOC101891116 {ECO:0000313|RefSeq:XP_005183029.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP59450.1};
RN [1] {ECO:0000313|EMBL:AFP59450.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP59450.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP59450.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA012561-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012561-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005183029.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005183029.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR602117-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602117-1};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the p53 family. {ECO:0000256|ARBA:ARBA00006167}.
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DR EMBL; KA644821; AFP59450.1; -; mRNA.
DR RefSeq; XP_005183029.1; XM_005182972.3.
DR EnsemblMetazoa; MDOA012561-RA; MDOA012561-PA; MDOA012561.
DR GeneID; 101891116; -.
DR KEGG; mde:101891116; -.
DR VEuPathDB; VectorBase:MDOA012561; -.
DR eggNOG; ENOG502QQ48; Eukaryota.
DR OrthoDB; 2902631at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR011615; p53_DNA-bd.
DR InterPro; IPR002117; p53_tumour_suppressor.
DR PANTHER; PTHR11447; CELLULAR TUMOR ANTIGEN P53; 1.
DR PANTHER; PTHR11447:SF16; P53 PROTEIN LONG FORM VARIANT 1; 1.
DR Pfam; PF00870; P53; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW DNA-binding {ECO:0000313|EMBL:AFP59450.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602117-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602117-1}.
FT DOMAIN 103..294
FT /note="p53 DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF00870"
FT REGION 329..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 178
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT BINDING 181
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT BINDING 248
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT BINDING 252
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
SQ SEQUENCE 425 AA; 48349 MW; 0DCF6870638F4116 CRC64;
MRKKNNRNTS NDAVESNINH TDVSVDSVQN VTNASLEEAQ PVYVSDASTV DIDENEQLTD
EPFTYLQNLN SGNLMKFSQQ SEIMNLMEQI VETKRNCNSI PVCEEHDNGG YDFGIQVNTT
DKASRYVFFS QDTQRLYVKP HEHVTIDCLY KIKMPIQPLN VRIMPIYTTG ASEPVRRCQN
HISKDNETNE IIRNSLLRCE NLGAVYYGSD TGKSIRDRYS VVVPLNAAVK VGDAGNHLKQ
QLIIHFTCNN SCMSRKPTSV LFLLENMSGE ILAQRMIAVK ISTCPKRDYR LYERPTGKKR
RPIGDPDFAS MTDAKMARYD DTCIKDEYSR SSYGDPSDDE ANASSVANGD CTESNVDVVL
DPTKGEYTLT LKYKTRHQML EVLRLLYSNA VTNEVFYKTS INGRKTRDTE HLKKCYEKTL
RLKLE
//
