ID T1P8X5_MUSDO Unreviewed; 365 AA.
AC T1P8X5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Spermine synthase isoform X2 {ECO:0000313|RefSeq:XP_005188878.1};
DE SubName: Full=Spermine/spermidine synthase {ECO:0000313|EMBL:AFP59224.1};
GN Name=101896722 {ECO:0000313|EnsemblMetazoa:MDOA010026-PA};
GN Synonyms=LOC101896722 {ECO:0000313|RefSeq:XP_005188878.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP59224.1};
RN [1] {ECO:0000313|EMBL:AFP59224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP59224.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP59224.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA010026-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010026-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005188878.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005188878.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
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DR EMBL; KA644595; AFP59224.1; -; mRNA.
DR RefSeq; XP_005188878.1; XM_005188821.3.
DR EnsemblMetazoa; MDOA010026-RA; MDOA010026-PA; MDOA010026.
DR GeneID; 101896722; -.
DR VEuPathDB; VectorBase:MDOA010026; -.
DR OrthoDB; 3059359at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016768; F:spermine synthase activity; IEA:InterPro.
DR GO; GO:0006597; P:spermine biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR InterPro; IPR015576; Spermine_synthase_animal.
DR PANTHER; PTHR46315; SPERMINE SYNTHASE; 1.
DR PANTHER; PTHR46315:SF1; SPERMINE SYNTHASE; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 2: Evidence at transcript level;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 124..364
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 279
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 365 AA; 41746 MW; B0CEFCAE2EC6E699 CRC64;
MAAQTVLFDF TVDPVRTSDP KERQEIAKVL RHELECLFPQ LEQQYQMPMD DGYFAVLTEN
KETIITVRIF GQGLVTINLE YYLEDGKEQL LSFDSSKRLE NNIAKKLKVV SGQVLPPLKR
GDFARYFPSS DERIIEYDID SLVYEARSPF QKIQIMHSKT LGNMLILDEL QNIAESDLIY
TETLMGRGVE NYEGKEICIL GGGDGALLYE LLKEKPKFVV MLEIDELVMQ ACNKYLNSIC
GDVLEKRKGD NYEIIVGDCV EYMKKFIADG RKFDYVFGDL TDIPISGAPI GECWDFIRTI
LEHSFKILKP DGKYLTHGNG TSCVESLELF EEQLGLLKPK VKFTTSKAFV PSFMEEWLFY
QVSLA
//
