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Database: UniProt
Entry: T1PAR7_MUSDO
LinkDB: T1PAR7_MUSDO
Original site: T1PAR7_MUSDO 
ID   T1PAR7_MUSDO            Unreviewed;       479 AA.
AC   T1PAR7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   18-SEP-2019, entry version 31.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   Name=101894836 {ECO:0000313|VectorBase:MDOA014364-PA};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP60428.1};
RN   [1] {ECO:0000313|EMBL:AFP60428.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ALHF {ECO:0000313|EMBL:AFP60428.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:AFP60428.1};
RA   Liu N., Zhang L., Li M., Reid W.;
RT   "Transcriptome of adult Musca domestica launches a platform for
RT   comparative house fly gene expression and characterization of
RT   differential gene expression among resistant and susceptible house
RT   flies.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA014364-PA}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA014364-PA};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [3] {ECO:0000313|VectorBase:MDOA014364-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA014364-PA};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Involved in the biosynthesis of glycosaminoglycans;
CC       hyaluronan, chondroitin sulfate, and heparan sulfate.
CC       {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; KA645799; AFP60428.1; -; mRNA.
DR   RefSeq; XP_005191114.1; XM_005191057.2.
DR   STRING; 7370.XP_005191114.1; -.
DR   GeneID; 101894836; -.
DR   KEGG; mde:101894836; -.
DR   VectorBase; MDOA014364-RA; MDOA014364-PA; MDOA014364.
DR   KO; K00012; -.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028356; UDPglc_DH_euk.
DR   PANTHER; PTHR11374; PTHR11374; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500133; UDPglc_DH_euk; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500133-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301}.
FT   DOMAIN      331    447       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   NP_BIND      10     15       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND      88     92       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND     129    130       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND     275    278       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   ACT_SITE    275    275       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500133-1}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING      40     40       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING     164    164       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING     345    345       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
SQ   SEQUENCE   479 AA;  53087 MW;  0A64DC666F6AEE80 CRC64;
     MSAMKVCCIG AGYVGGPTCS VMALKCPDIT VTVVDKSSER IAQWNSDKLP IYEPGLDDVV
     KKCRNVNLFF STDIETAIKE ADLIFISVNT PTKTFGNGKG RAADLKYVES AARMIAEIAQ
     SNKIVVEKST VPVRAAESIM HILHANQKPG IRYDILSNPE FLAEGTAIED LLHADRVLIG
     GEETPEGHKA IEKLSWIYEH WIPKENILTT NTWSSELSKL AANAFLAQRI SSINSLSAVC
     EATGGDVSEV ARAIGLDSRI GPKFLQASVG FGGSCFQKDI LNLVYICEGL NLPEVAAYWQ
     QVIDMNEYQK SRFSQKIIEC LFNTVSNKHI SILGFAFKKN TGDTRETPAI TVCKTLLEEG
     AKLDIYDPKV EPEQIIDDLT HPSVTESPEG VKQAVQIHSD PYSAVRGTHA IVLCTEWDEF
     VTLDYQRIYQ SMMKPAYIFD GRKILDHERL QQIGFHVQTI GKKYSRSGLM RSWGSVQQL
//
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