ID T1PAX7_MUSDO Unreviewed; 768 AA.
AC T1PAX7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=KCNQ voltage-gated potassium channel {ECO:0000313|EMBL:AFP60516.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP60516.1};
RN [1] {ECO:0000313|EMBL:AFP60516.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP60516.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP60516.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA015117-PK}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA015117-PK};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KA645887; AFP60516.1; -; mRNA.
DR AlphaFoldDB; T1PAX7; -.
DR STRING; 7370.T1PAX7; -.
DR EnsemblMetazoa; MDOA015117-RK; MDOA015117-PK; MDOA015117.
DR VEuPathDB; VectorBase:MDOA015117; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735:SF9; POTASSIUM VOLTAGE-GATED CHANNEL KQT-LIKE SUBFAMILY, INVERTEBRATE; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000313|EMBL:AFP60516.1};
KW Ion transport {ECO:0000313|EMBL:AFP60516.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:AFP60516.1}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..270
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 378..499
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 507..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 86506 MW; 5744B30114F87C92 CRC64;
MSLLGKPINY NRGNRRDVRY RRLQSRVYNF LERPRGLPAV LYHVMVFLMV FTCLALSVFS
TIKEYEEDAL YILFRMEILV VIWFTMEFFL RLWSSGCRSR YQGCVGRLKF VKRPFCIIDI
ITIVASVVVL GMGTSGQVFA TSALRGLRFF QILRMVRMDR RGGTWKLLGS VVYAHRQELI
TTMYIGFLGL IFASFLVYLM EKDVNDKFNN FAQALWWGVI TLCTVGYGDM VPETWQGKLI
ASFCALLGIS FFALPAGILG SGFALKVQQQ QRQKHMIRRR QPAASLIQAL WRCYAADEHS
SSVATWKIHQ VALPSPPASR ASSSFKHNAS FVARLPTIRR HKPPTSTQSP GGDSLSVKTA
VATNRVSRYT RNLRELNQSV ENLDEDDEPR CTQLTNKHKT AIRFIRKLKY FVARRKFKEA
LKPYDVKDVM EQYAAGHVDL LGRVKNVHAR LDQILGKQGS KSKDAYASKI SLASRVVKVE
RQVADIEEKL DILIKAYMED RQRFQTLPPT PQVSKHSNNN NHLPNIIENS QSGIVNTNKK
SNEWINRSAK MADATTSTAA LAAMALDQAS SSTSSQAQQG TTEPEYTKSS QNSSYPLSVD
PRPISVYKQR GSDGFIAEIE SRSKKRVTLR SISQPYDKVC QVDEVSISIP TTESQSLGSS
PSQQRPESSI ILIDEYEDVE EEDLNCEEEF DEYHPSWEID SDAIVDADAD VDGDETTEDT
ALLHRPTRTA IVITPISPVN SAHNLQSMDD QSNAPTINKS NLLSPDSG
//
