ID T1PEX1_MUSDO Unreviewed; 220 AA.
AC T1PEX1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=AhpC/TSA family {ECO:0000313|EMBL:AFP61971.1};
DE SubName: Full=Peroxiredoxin-6 {ECO:0000313|RefSeq:XP_005174855.1};
GN Name=101888226 {ECO:0000313|EnsemblMetazoa:MDOA001009-PA};
GN Synonyms=LOC101888226 {ECO:0000313|RefSeq:XP_005174855.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP61971.1};
RN [1] {ECO:0000313|EMBL:AFP61971.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP61971.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP61971.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA001009-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA001009-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005174855.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005174855.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC respectively. {ECO:0000256|PIRNR:PIRNR000239}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin family. Prx6 subfamily.
CC {ECO:0000256|ARBA:ARBA00025719}.
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DR EMBL; KA647342; AFP61971.1; -; mRNA.
DR RefSeq; XP_005174855.1; XM_005174798.3.
DR STRING; 7370.T1PEX1; -.
DR EnsemblMetazoa; MDOA001009-RA; MDOA001009-PA; MDOA001009.
DR GeneID; 101888226; -.
DR KEGG; mde:101888226; -.
DR VEuPathDB; VectorBase:MDOA001009; -.
DR eggNOG; KOG0854; Eukaryota.
DR OrthoDB; 103042at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0051920; F:peroxiredoxin activity; IEA:InterPro.
DR CDD; cd03016; PRX_1cys; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR InterPro; IPR019479; Peroxiredoxin_C.
DR InterPro; IPR045020; PRX_1cys.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR43503:SF3; DI01187P-RELATED; 1.
DR PANTHER; PTHR43503; MCG48959-RELATED; 1.
DR Pfam; PF10417; 1-cysPrx_C; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR PIRSF; PIRSF000239; AHPC; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Antioxidant {ECO:0000256|ARBA:ARBA00022862, ECO:0000256|PIRNR:PIRNR000239};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000239};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|PIRNR:PIRNR000239};
KW Redox-active center {ECO:0000256|ARBA:ARBA00023284,
KW ECO:0000256|PIRNR:PIRNR000239};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 1..164
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT ACT_SITE 43
FT /note="Cysteine sulfenic acid (-SOH) intermediate; for
FT peroxidase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
SQ SEQUENCE 220 AA; 24945 MW; 5E00156024E000CF CRC64;
MRLGSTVPNF KCDSTKGPIQ FYDWQGDSWV VLFSHPADFT PVCTTELGRI AVHAPEFNKR
NTKLLAHSVD QLKSHVDWVN DIKSYCLDIP GEFPYPILAD PTRELAVQFG MLDEQQRQDP
EVGKTIRALF IISPDHKVRL SMFYPMSTGR NVDEILRCID SLQLTDRLKV VATPANWTPG
TKVMIIPSVT DEEAHKLFPK GFDKVSMPSG VNYVRTTENY
//
