ID T1PI33_MUSDO Unreviewed; 457 AA.
AC T1PI33;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
GN Name=101901006 {ECO:0000313|EnsemblMetazoa:MDOA015282-PB};
GN Synonyms=LOC101901006 {ECO:0000313|RefSeq:XP_005179784.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP62424.1};
RN [1] {ECO:0000313|EMBL:AFP62424.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP62424.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP62424.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA015282-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA015282-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005179784.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005179784.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00277};
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DR EMBL; KA647795; AFP62424.1; -; mRNA.
DR RefSeq; XP_005179784.1; XM_005179727.3.
DR STRING; 7370.T1PI33; -.
DR EnsemblMetazoa; MDOA015282-RB; MDOA015282-PB; MDOA015282.
DR GeneID; 101901006; -.
DR KEGG; mde:101901006; -.
DR VEuPathDB; VectorBase:MDOA015282; -.
DR eggNOG; KOG0543; Eukaryota.
DR OrthoDB; 25281at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46512; PEPTIDYLPROLYL ISOMERASE; 1.
DR PANTHER; PTHR46512:SF9; TETRATRICOPEPTIDE REPEAT DOMAIN 9; 1.
DR Pfam; PF00254; FKBP_C; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54534; FKBP-like; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 2.
DR PROSITE; PS50005; TPR; 2.
PE 2: Evidence at transcript level;
KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277,
KW ECO:0000313|EMBL:AFP62424.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 35..123
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT DOMAIN 152..238
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT REPEAT 255..288
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 332..365
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 457 AA; 51262 MW; 4B2B1857E1487FB6 CRC64;
MTAGEVLEKV TITPDGGVQK DILKYGTGDE TPENGCKVSL HYTGRLTDGT VFDSSVDRGE
PFEFELGARS VIKAFDLGVI TMKLGEKCNL ICAPEYAYGE SGSPPSIPPN ATLIFELEML
GWMGADVSPN KDGSIERFTI VSSDKRRGPN DGSLCKAHIT GKYDGKVFEE RDVEFNLGEG
SDIGLVEGVE VAIGKMVIGE ESRFKIKPKY AFGAKGNEQF NIPPNATVEY IIKLNDCEKG
IEDWKFTEEE RVEHSKIYKE KGTKYFKKEN FSLALKMYKK CVDILDNNSD EESNKLKAAA
FSNQALCHQK LNEHFEAKQA CNETLKLEPN NIKALYRRGQ CNVTVAEYDD ALLDFQKVLE
LEPTNKAAQN QIQICKHKIK EAKDKEKRIY ANMFTKLAAA DKEQDEKPED DVLAKCGEWK
DEDANLASER KSGDEWTDED TKREADYALE RDNIVMI
//
