ID T1T093_STACP Unreviewed; 668 AA.
AC T1T093;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Beta-lactam-inducible penicillin-binding protein 2 {ECO:0000313|EMBL:AGT56837.1};
OS Staphylococcus capitis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=29388 {ECO:0000313|EMBL:AGT56837.1};
RN [1] {ECO:0000313|EMBL:AGT56837.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CR01 {ECO:0000313|EMBL:AGT56837.1};
RX PubMed=24060879;
RA Martins Simoes P., Rasigade J.P., Lemriss H., Butin M., Ginevra C.,
RA Lemriss S., Goering R.V., Ibrahimi A., Picaud J.C., El Kabbaj S.,
RA Vandenesch F., Laurent F.;
RT "Characterization of a Novel Composite Staphylococcal Cassette Chromosome
RT mec (SCCmec-SCCcad/ars/cop) in the Neonatal Sepsis-Associated
RT Staphylococcus capitis Pulsotype NRCS-A.";
RL Antimicrob. Agents Chemother. 57:6354-6357(2013).
RN [2] {ECO:0000313|EMBL:AGT56837.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CR01 {ECO:0000313|EMBL:AGT56837.1};
RA Simoes P.M., Lemriss H., Rasigade J.-P., Lemriss S., Laurent F.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; KF049201; AGT56837.1; -; Genomic_DNA.
DR AlphaFoldDB; T1T093; -.
DR SMR; T1T093; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..140
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 148..310
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 346..656
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 668 AA; 76172 MW; BC91CDD1C5C17A4F CRC64;
MKKIKIVPLI LIVVVVGFGI YFYASKDKEI NNTIDAIEDK NFKQVYKDSS YISKSDNGEV
EMTERPIKIY NSLGVKDINI QDRKIKKVSK NKKRVDAQYK IKTNYGNIDR NVQFNFVKED
GMWKLDWDHS VIIPGMQKDQ SIHIENLKSE RGKILDRNNV ELANTGTAYE IGIVPKNVSK
KDYKAIAKEL SISEDYIKQQ MDQNWVQDDT FVPLKTVKKM DEYLRDFAKK FHLTTNETES
RNYPLGKATS HLLGYVGPIN SEELKQKEYK GYKDDAVIGK KGLEKLYDKK LQHEDGYRVT
IVDDNSNTIA HTLIEKKKKD GKDIQLTIDA KVQKSIYNNM KNDYGSGTAI HPQTGELLAL
VSTPSYDVYP FMYGMSNEEY NKLTEDKKEP LLNKFQITTS PGSTQKILTA MIGLNNKTLD
DKTSYKIDGK GWQKDKSWGG YNVTRYEVVN GNIDLKQAIE SSDNIFFARV ALELGSKKFE
KGMKKLGVGE DIPSDYPFYN AQISNKNLDN EILLADSGYG QGEILINPVQ ILSIYSALEN
NGNINAPHLL KDTKNKVWKK NIISKENINL LTDGMQQVVN KTHKEDIYRS YANLIGKSGT
AELKMKQGET GRQIGWFISY DKDNPNMMMA INVKDVQDKG MASYNAKISG KVYDELYENG
NKKYDIDE
//
