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Database: UniProt
Entry: T1ZGH2_STRIT
LinkDB: T1ZGH2_STRIT
Original site: T1ZGH2_STRIT 
ID   T1ZGH2_STRIT            Unreviewed;       212 AA.
AC   T1ZGH2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165,
GN   ECO:0000313|EMBL:AGU76577.1};
GN   ORFNames=SIR_1216 {ECO:0000313|EMBL:AGU76577.1};
OS   Streptococcus intermedius B196.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus; Streptococcus anginosus group.
OX   NCBI_TaxID=862967 {ECO:0000313|EMBL:AGU76577.1, ECO:0000313|Proteomes:UP000016233};
RN   [1] {ECO:0000313|EMBL:AGU76577.1, ECO:0000313|Proteomes:UP000016233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B196 {ECO:0000313|EMBL:AGU76577.1,
RC   ECO:0000313|Proteomes:UP000016233};
RX   PubMed=24341328; DOI=10.1186/1471-2164-14-895;
RA   Olson A.B., Kent H., Sibley C.D., Grinwis M.E., Mabon P., Ouellette C.,
RA   Tyson S., Graham M., Tyler S.D., Van Domselaar G., Surette M.G.,
RA   Corbett C.R.;
RT   "Phylogenetic relationship and virulence inference of Streptococcus
RT   Anginosus Group: curated annotation and whole-genome comparative analysis
RT   support distinct species designation.";
RL   BMC Genomics 14:895-895(2013).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00001008, ECO:0000256|HAMAP-
CC         Rule:MF_00165};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00009776, ECO:0000256|HAMAP-Rule:MF_00165}.
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DR   EMBL; CP003857; AGU76577.1; -; Genomic_DNA.
DR   RefSeq; WP_021003002.1; NZ_UZBH01000003.1.
DR   AlphaFoldDB; T1ZGH2; -.
DR   KEGG; sib:SIR_1216; -.
DR   PATRIC; fig|862967.3.peg.1229; -.
DR   eggNOG; COG0125; Bacteria.
DR   HOGENOM; CLU_049131_0_2_9; -.
DR   OrthoDB; 9774907at2; -.
DR   Proteomes; UP000016233; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01672; TMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   NCBIfam; TIGR00041; DTMP_kinase; 1.
DR   PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR   PANTHER; PTHR10344:SF4; UMP-CMP KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:AGU76577.1};
KW   Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727, ECO:0000256|HAMAP-
KW   Rule:MF_00165}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016233};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00165}.
FT   DOMAIN          9..197
FT                   /note="Thymidylate kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00165"
SQ   SEQUENCE   212 AA;  23748 MW;  071D1E998207A8DC CRC64;
     MSKGMFISLE GPDGAGKSSV LEALIPILET KGQAFITTRE PGGVAVAEKI RDVILDPKHT
     EIDEKTELLL YIASRRQHLV ERIVPALNRG ELVLVDRFID SSVAYQGFGR GLKVADIDWL
     NNFATDGLKP DLTLYFDIDV EEGLARIAKS KDRGADRLDR ESVEWHKRVR EGYLSILEKE
     PNRMKRIDAS QPLEKVISDT VAVLAEHVES LR
//
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