ID T1ZHI3_STRIT Unreviewed; 255 AA.
AC T1ZHI3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Uridine phosphorylase {ECO:0000256|ARBA:ARBA00021980};
DE EC=2.4.2.3 {ECO:0000256|ARBA:ARBA00011888};
GN ORFNames=SIR_1583 {ECO:0000313|EMBL:AGU76932.1};
OS Streptococcus intermedius B196.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus; Streptococcus anginosus group.
OX NCBI_TaxID=862967 {ECO:0000313|EMBL:AGU76932.1, ECO:0000313|Proteomes:UP000016233};
RN [1] {ECO:0000313|EMBL:AGU76932.1, ECO:0000313|Proteomes:UP000016233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B196 {ECO:0000313|EMBL:AGU76932.1,
RC ECO:0000313|Proteomes:UP000016233};
RX PubMed=24341328; DOI=10.1186/1471-2164-14-895;
RA Olson A.B., Kent H., Sibley C.D., Grinwis M.E., Mabon P., Ouellette C.,
RA Tyson S., Graham M., Tyler S.D., Van Domselaar G., Surette M.G.,
RA Corbett C.R.;
RT "Phylogenetic relationship and virulence inference of Streptococcus
RT Anginosus Group: curated annotation and whole-genome comparative analysis
RT support distinct species designation.";
RL BMC Genomics 14:895-895(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001020};
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DR EMBL; CP003857; AGU76932.1; -; Genomic_DNA.
DR RefSeq; WP_021003205.1; NZ_UZBH01000002.1.
DR AlphaFoldDB; T1ZHI3; -.
DR KEGG; sib:SIR_1583; -.
DR PATRIC; fig|862967.3.peg.1604; -.
DR eggNOG; COG2820; Bacteria.
DR HOGENOM; CLU_068457_1_0_9; -.
DR OrthoDB; 7945729at2; -.
DR Proteomes; UP000016233; Chromosome.
DR GO; GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0004850; F:uridine phosphorylase activity; IEA:RHEA.
DR GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR CDD; cd09007; NP-I_spr0068; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR PANTHER; PTHR43691:SF11; FI09636P-RELATED; 1.
DR PANTHER; PTHR43691; URIDINE PHOSPHORYLASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:AGU76932.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016233};
KW Transferase {ECO:0000313|EMBL:AGU76932.1}.
FT DOMAIN 64..242
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 255 AA; 28892 MW; 0075B229247CD447 CRC64;
MLLEEFEDVA GVIEPTDRQI IDKGEVCETI ILSFNGEILK RLIESEEVYP GGYLKSINGQ
HPWYIYGQGP SKLAVMLAPI GAPMIVGQLE ELAARGFKNF IILGSCGVLD RSIEADKIIL
PAAALRDEGT SYHYAPPGDE VAYDESLLVE LEAIFDKHDI EHIRTKSWTT DAFYRETPEK
VKRRLAAGAK VVDMEASAIM AWSQFRKTKV YQFFYTADYV DHHNRTWDAR HEERKADAMT
FFTIALAIAK ELERN
//
