ID T2BNQ3_CRYNH Unreviewed; 519 AA.
AC T2BNQ3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Phospholipid transporter, variant {ECO:0000313|EMBL:AGV14346.1};
GN ORFNames=CNAG_01055 {ECO:0000313|EMBL:AGV14346.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AGV14346.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AGV14346.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003824; AGV14346.1; -; Genomic_DNA.
DR RefSeq; XP_012049285.1; XM_012193895.1.
DR AlphaFoldDB; T2BNQ3; -.
DR GeneID; 23884801; -.
DR VEuPathDB; FungiDB:CNAG_01055; -.
DR HOGENOM; CLU_001265_46_12_1; -.
DR OrthoDB; 1698487at2759; -.
DR Proteomes; UP000010091; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23508; CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR23508:SF11; MAJOR GLYCEROPHOSPHOINOSITOL PERMEASE GIT3; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..459
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 519 AA; 56597 MW; 3D693137BE35064C CRC64;
MRLPWIKKNV DLEPKTGDEP HDSNFIEKKL GLSKKGAIFA AGASLFSDGY ANASIGPATT
IIKTYVYPDL FESRPVNSRL LPAIAFAGII VGQLSFGWIS DKVGRKFGML LCTGIVFVFS
ALQAASKGVG GAQGTINALI AYRFLVGIGI GGEYPTGSVA AAENTEDPDI PKASQQRLFV
LATNSMIDAA FVISYFVCLV LLWIFGMNHL NAVWRMTLGL GCVPPLFLFY FRLKMKEPES
YEKYSMKHTR IPYWLIIKRY WVKLAAVSIT WFLYDWITYP FGLYATPITD AADPNGTLYT
SIGWGCLINF FYLPGTLFGA FIVDYLGPKY CMIFGLCMQA IFGFVLSGCY NLLTQPHRIA
GFAILYGFFL SFGEVGPGNN LGLLASKAIG PTAARGQLYG IAAAVGKVGA FIGTYTFPQI
QASFGKHGQY AEDTGVFYLG SALALVSALI TLIFIPNIQP DAMHDEDIAF REYLEANGFD
TSKMGLKDSA SDVEVGDGSG DEKNNKISNE RIETHALAI
//
