ID   T2BP68_CRYNH            Unreviewed;       371 AA.
AC   T2BP68;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Thioesterase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CNAG_05741 {ECO:0000313|EMBL:AGV14478.1};
OS   Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS   CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=235443 {ECO:0000313|EMBL:AGV14478.1, ECO:0000313|Proteomes:UP000010091};
RN   [1] {ECO:0000313|EMBL:AGV14478.1, ECO:0000313|Proteomes:UP000010091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC   {ECO:0000313|Proteomes:UP000010091};
RX   PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA   Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA   Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA   Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA   Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA   Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA   Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA   Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA   Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA   Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA   Cuomo C.A., Dietrich F.S.;
RT   "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT   grubii reveals complex RNA expression and microevolution leading to
RT   virulence attenuation.";
RL   PLoS Genet. 10:E1004261-E1004261(2014).
CC   -!- SIMILARITY: Belongs to the lcsJ thioesterase family.
CC       {ECO:0000256|ARBA:ARBA00038476}.
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DR   EMBL; CP003826; AGV14478.1; -; Genomic_DNA.
DR   RefSeq; XP_012050490.1; XM_012195100.1.
DR   AlphaFoldDB; T2BP68; -.
DR   GeneID; 23889034; -.
DR   VEuPathDB; FungiDB:CNAG_05741; -.
DR   HOGENOM; CLU_043860_1_0_1; -.
DR   OrthoDB; 2734334at2759; -.
DR   Proteomes; UP000010091; Chromosome 7.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   PANTHER; PTHR12475; -; 1.
DR   PANTHER; PTHR12475:SF4; PROTEIN THEM6; 1.
DR   Pfam; PF13279; 4HBT_2; 1.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
PE   3: Inferred from homology;
FT   REGION          218..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  41127 MW;  7E501FCB392F7730 CRC64;
     MELLSQVPTS LVSGLRSLIG SVTSSSTPLL PFISKPVKLI LLLLFLSHSP SWPFVWHVRV
     WWHGVKAYYL AWHKGRARYL ADWKAQNDKD GGIRGLRVRH KRIAGVDDCD YNMHLSNSSY
     AKNSDALKMD WCIKALSPSF TARGTYMALG ATHYVFFKEI PIGSEYTMEA YCLGWDEKWM
     YLACEFILYP KKTSKAGAAK NKVAAGVVSS APHIVPTISA PPTRTASPNS SASVSGNVTP
     AQGSPLGNKV EEIKRAWLAR RKENPRGDGG VTCCLSVSEY CFKIDRVTIP PRISLYTSLQ
     SPSKEHQDRA RAMLMSKDGG RAFLRGGWRE EINSELLGAD IGLVEGEEFQ DSWVKRAAES
     MEKVVDGMSA F
//