ID T2R41_HUMAN Reviewed; 307 AA.
AC P59536; P59550; Q495I2; Q50KJ5; Q50KJ6; Q50KJ7; Q645W7;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 24-JAN-2024, entry version 143.
DE RecName: Full=Taste receptor type 2 member 41;
DE Short=T2R41;
DE AltName: Full=Taste receptor type 2 member 59;
DE Short=T2R59;
GN Name=TAS2R41;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12584440; DOI=10.1159/000068546;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Identification and characterization of human taste receptor genes
RT belonging to the TAS2R family.";
RL Cytogenet. Genome Res. 98:45-53(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-127.
RX PubMed=12379855; DOI=10.1038/ng1014;
RA Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.;
RT "The human TAS2R16 receptor mediates bitter taste in response to beta-
RT glucopyranosides.";
RL Nat. Genet. 32:397-401(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-127.
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
RX PubMed=15744053; DOI=10.1534/genetics.104.037523;
RA Go Y., Satta Y., Takenaka O., Takahata N.;
RT "Lineage-specific loss of function of bitter taste receptor genes in humans
RT and nonhuman primates.";
RL Genetics 170:313-326(2005).
RN [7]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [8]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [9]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P59536; Q6ICB0: DESI1; NbExp=3; IntAct=EBI-13344991, EBI-2806959;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and exclusively in gustducin-positive cells.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY114093; AAM63543.1; -; Genomic_DNA.
DR EMBL; AF494232; AAM19323.1; -; Genomic_DNA.
DR EMBL; AY724956; AAU21152.1; -; Genomic_DNA.
DR EMBL; AC073264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101157; AAI01158.1; -; mRNA.
DR EMBL; BC101158; AAI01159.1; -; mRNA.
DR EMBL; AB199177; BAD98051.1; -; Genomic_DNA.
DR EMBL; AB199178; BAD98052.1; -; Genomic_DNA.
DR EMBL; AB199179; BAD98053.1; -; Genomic_DNA.
DR CCDS; CCDS43663.1; -.
DR RefSeq; NP_795364.2; NM_176883.2.
DR AlphaFoldDB; P59536; -.
DR SMR; P59536; -.
DR BioGRID; 129242; 21.
DR IntAct; P59536; 15.
DR STRING; 9606.ENSP00000386201; -.
DR BindingDB; P59536; -.
DR ChEMBL; CHEMBL3309108; -.
DR GlyCosmos; P59536; 1 site, No reported glycans.
DR GlyGen; P59536; 1 site.
DR iPTMnet; P59536; -.
DR PhosphoSitePlus; P59536; -.
DR BioMuta; TAS2R41; -.
DR DMDM; 261260079; -.
DR PaxDb; 9606-ENSP00000386201; -.
DR PeptideAtlas; P59536; -.
DR Antibodypedia; 32664; 108 antibodies from 19 providers.
DR DNASU; 259287; -.
DR Ensembl; ENST00000408916.1; ENSP00000386201.1; ENSG00000221855.1.
DR Ensembl; ENST00000646750.1; ENSP00000494656.1; ENSG00000284982.1.
DR GeneID; 259287; -.
DR KEGG; hsa:259287; -.
DR MANE-Select; ENST00000408916.1; ENSP00000386201.1; NM_176883.2; NP_795364.2.
DR UCSC; uc003wdc.1; human.
DR AGR; HGNC:18883; -.
DR CTD; 259287; -.
DR GeneCards; TAS2R41; -.
DR HGNC; HGNC:18883; TAS2R41.
DR HPA; ENSG00000221855; Not detected.
DR MIM; 613965; gene.
DR neXtProt; NX_P59536; -.
DR PharmGKB; PA38737; -.
DR VEuPathDB; HostDB:ENSG00000221855; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; P59536; -.
DR OMA; LHWDFLN; -.
DR OrthoDB; 4642354at2759; -.
DR PhylomeDB; P59536; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; P59536; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR SignaLink; P59536; -.
DR BioGRID-ORCS; 259287; 9 hits in 1138 CRISPR screens.
DR GeneWiki; TAS2R41; -.
DR GenomeRNAi; 259287; -.
DR Pharos; P59536; Tchem.
DR PRO; PR:P59536; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P59536; Protein.
DR Bgee; ENSG00000221855; Expressed in hindlimb stylopod muscle.
DR Genevisible; P59536; HS.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR CDD; cd15018; 7tm_TAS2R41-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF73; TASTE RECEPTOR TYPE 2 MEMBER 41; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..307
FT /note="Taste receptor type 2 member 41"
FT /id="PRO_0000082295"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 127
FT /note="P -> L (in dbSNP:rs10278721)"
FT /evidence="ECO:0000269|PubMed:12379855,
FT ECO:0000269|PubMed:15496549"
FT /id="VAR_060211"
FT CONFLICT 207
FT /note="L -> M (in Ref. 6; BAD98053)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 35896 MW; 7A33E3ED3E44E563 CRC64;
MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS LGASRFCLQL
VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC SWLSVLFCVK IANITHSTFL
WLKWRFPGWV PWLLLGSVLI SFIITLLFFW VNYPVYQEFL IRKFSGNMTY KWNTRIETYY
FPSLKLVIWS IPFSVFLVSI MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL
ILYALSFLSL IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL
ARGFWVA
//
