ID   T5A689_OPHSC            Unreviewed;        76 AA.
AC   T5A689;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein {ECO:0000256|RuleBase:RU364120};
GN   ORFNames=OCS_06371 {ECO:0000313|EMBL:EQK97915.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQK97915.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQK97915.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQK97915.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- FUNCTION: Interacts with target proteins during translocation into the
CC       lumen of the endoplasmic reticulum. Protects unfolded target proteins
CC       against degradation and facilitate correct glycosylation.
CC       {ECO:0000256|RuleBase:RU364120}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU364120}. Endoplasmic
CC       reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-pass
CC       membrane protein {ECO:0000256|RuleBase:RU364120}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family.
CC       {ECO:0000256|ARBA:ARBA00005500, ECO:0000256|RuleBase:RU364120}.
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DR   EMBL; KE656137; EQK97915.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5A689; -.
DR   eggNOG; ENOG502SDGZ; Eukaryota.
DR   HOGENOM; CLU_182424_0_0_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   Pfam; PF06624; RAMP4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU364120};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364120};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU364120};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU364120}.
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364120"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   76 AA;  8662 MW;  1FAC12DFAA3C79BA CRC64;
     MSASPPLKKA QTLEQRRRNA KFAKDQEARM GRSEEQVKKR VKEAPKSSIS MFWIAILGFV
     VFGGLMFEGL ARMFGR
//