ID   T5A6K3_OPHSC            Unreviewed;       723 AA.
AC   T5A6K3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE   AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
GN   ORFNames=OCS_03194 {ECO:0000313|EMBL:EQL01100.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL01100.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL01100.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL01100.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365006}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC       {ECO:0000256|RuleBase:RU365006}.
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DR   EMBL; KE652592; EQL01100.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5A6K3; -.
DR   eggNOG; KOG1135; Eukaryota.
DR   HOGENOM; CLU_002227_3_0_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR   CDD; cd16293; CPSF2-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027075; CPSF2.
DR   InterPro; IPR025069; Cpsf2_C.
DR   InterPro; IPR035639; CPSF2_MBL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF13299; CPSF100_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|RuleBase:RU365006};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW   RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT   DOMAIN          286..443
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
FT   REGION          509..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  78843 MW;  C5CBD976E1D7BEA5 CRC64;
     MFTFCPLQGA LSESTASQSL LELDGGVKVL VDLGWDESFD VEKLAELEKQ VPTLSLILLT
     HATVSHLAAY VHCCKNFPLF TRVPAYATRP VIDLGRSLTQ DLYSSTPTAC TTISQSSLSE
     LAYAYSQTAS TASTAQNLLL QSPTPDDIAR YFSLIQPLKY SQPHQPLPSP FSPPLNGLTI
     TAYNAGHTLG GTIWHIQHGL ESIVYAVDWN QARENVFAGA AWLDGAAGGG AEVIEQLRKP
     TALICSSRVA QAGGRIKRDE SLIDTIKACV SKGGTVLIPV DSSARVLEMA YFLEHAWRLD
     ASSKGGNLRS AKLYLAGRNM SSTMRYARSM LEWMDNNIVQ EFEACAEGQR RANGANDRKE
     AGPFDFKHLR LLERKAQITK LLSRVSHHGE SEGRVILASD SSMEWGFSKD LIKGLAGDSR
     NLVILTDRPS MAKDGNESVA RTLWEWWRER RDGVSVEQTA GGDQLEMVYG GGRELQLRQA
     ARQALEGDEL AVYQQWLVTQ RQLQATQHTG GAAALEASAD VDDASSDSSS DSEDDDGQQQ
     GKALTVSATM GQAGRKNVVL KDEDLGINVL MKKKGVYDFD SRGKRGRERS FPLAVRRKRN
     DDFGELIRPE DYLRAEEKDE DNADGGNVAA VDDKLGKKRK WGDPLHVGDL RLADLRRAMQ
     GAGHGAEFRG EGMLVVDGSV VVRKTTEGRV EVESVGVPAG ARRNTVFAVK RAIYEGLAVV
     AGA
//