ID T5AD31_OPHSC Unreviewed; 630 AA.
AC T5AD31;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC3 {ECO:0000256|RuleBase:RU367076};
DE Short=RNA polymerase III subunit C3 {ECO:0000256|RuleBase:RU367076};
GN ORFNames=OCS_03786 {ECO:0000313|EMBL:EQL00504.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL00504.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL00504.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL00504.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific core component of RNA polymerase III which synthesizes small
CC RNAs, such as 5S rRNA and tRNAs. {ECO:0000256|ARBA:ARBA00025127,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000256|ARBA:ARBA00011206,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC {ECO:0000256|ARBA:ARBA00006835, ECO:0000256|RuleBase:RU367076}.
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DR EMBL; KE652796; EQL00504.1; -; Genomic_DNA.
DR AlphaFoldDB; T5AD31; -.
DR eggNOG; KOG2587; Eukaryota.
DR HOGENOM; CLU_023294_0_0_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR InterPro; IPR039748; RPC3.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR12949:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3; 1.
DR PANTHER; PTHR12949; RNA POLYMERASE III DNA DIRECTED -RELATED; 1.
DR Pfam; PF08221; HTH_9; 1.
DR Pfam; PF05645; RNA_pol_Rpc82; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU367076}; Nucleus {ECO:0000256|RuleBase:RU367076};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367076}.
FT DOMAIN 2..47
FT /note="RNA polymerase III subunit RPC82-related helix-turn-
FT helix"
FT /evidence="ECO:0000259|Pfam:PF08221"
FT DOMAIN 141..463
FT /note="RNA polymerase III Rpc82 C -terminal"
FT /evidence="ECO:0000259|Pfam:PF05645"
FT REGION 108..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70762 MW; 38D9E0256D5733E6 CRC64;
MQRVLAALLM NGRSSIIQLA QNTSLSPRHL RNGLGVLIQQ NLLFYSTDSD TSATSYEANI
DACYNLVRSG KILEVVESQH GRAGRDLVQT LLLLGCARVA DLTHAFGSRA PNSNPNSNGH
ANGTHQSGSG LIESEDHLHM VLTRLIQDEV VETVRPDSLR NPAEVYREIE AEVTKTAPGE
KASRNKIEQH MHIVERYQAF RDQSRTLKRQ LDKANGPVAK RMKLQNGNAH ADDPFADDLL
PLNPDVVVRI NHGKCLVQLR NQRLAEFAAD ALGEATGQVY HALLELLTVQ LARCRPDQLS
GDQGGSQQIT VSSIEVYEHL DEGVNVQSGI GKAPREKIDF QSAEKVRPSP LDCESDSDDP
DVRPPVRGRA SRTVTSGGHD EFDESSDDDG HRAKGSRSAS GVNGDRQTKV KFEDEAASKD
NRLDQMRQHL LLLAESKHRF VRHCGINGRG QWTVDFGQLM ESLREAELDA YIQQSFGRHG
LRLTRILREK GKLDEKMLPS AALMKKSDVQ GKMLAMQMAG LVDVQEVPKD NSRLANRTLF
FWFFDGERTQ SQLLDDVYKA MLRCLQTLQV ERHKERNILS FVERKDVKGK EEEVMTAEHY
NKYNRHLEEQ EKLLGQVMRL DDMVAVLRDY
//
