ID   T5AJD5_OPHSC            Unreviewed;       355 AA.
AC   T5AJD5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Alcohol dehydrogenase superfamily, zinc-type {ECO:0000313|EMBL:EQL02521.1};
GN   ORFNames=OCS_01776 {ECO:0000313|EMBL:EQL02521.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02521.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL02521.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02521.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
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DR   EMBL; KE652301; EQL02521.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5AJD5; -.
DR   eggNOG; KOG1196; Eukaryota.
DR   HOGENOM; CLU_026673_29_2_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205:SF42; ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530); 1.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT   DOMAIN          21..337
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   355 AA;  38355 MW;  2A1C4BFB8D83C1C8 CRC64;
     MAQQNLSFVL AERPTGGISV GKTLARKTSP IPSASDLEDG QVLVEVLYLS LDPAMRGWMS
     ELPSYLPPVK IGETMRGQAA CRVVASKSAK INKGDFVSGP AGWTQYAVLD EKKLEPSASY
     PNLKYSVDML SALGHTSLAA WVGMTKIGLP KAGETVVVSG AAGATGSVAG QIAKIAGARV
     VGLCGSDYKC KWLVDELGFD VALNYKAADF RDRFKEATES YIDVYFDTVG GDILDLALCR
     AKKHARFVEC GQISQYAAST RKGPANIIAV VAMRIRMQGF IVFDHVQDFP RARNELARWL
     AEGKLKRTEH ILSGGLEVAE QGLIDLYKGV NLGKLIVEVK PKKRPLVKVT LSITY
//