ID   T5AK87_OPHSC            Unreviewed;       576 AA.
AC   T5AK87;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Dihydroxy-acid dehydratase {ECO:0000313|EMBL:EQL02228.1};
GN   ORFNames=OCS_02054 {ECO:0000313|EMBL:EQL02228.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02228.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL02228.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02228.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
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DR   EMBL; KE652335; EQL02228.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5AK87; -.
DR   eggNOG; KOG2448; Eukaryota.
DR   HOGENOM; CLU_014271_4_2_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   PANTHER; PTHR21000; DIHYDROXY-ACID DEHYDRATASE DAD; 1.
DR   PANTHER; PTHR21000:SF5; DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00920; ILVD_EDD; 2.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
SQ   SEQUENCE   576 AA;  61677 MW;  BC007BEBA4ED4855 CRC64;
     MLSTALRQRL GRASLASSNN HGRLFSTTAA RLAEDKLNRV SSVITQPKSQ GASQAMLYAT
     GLSEDDMNKA QIGISSVWYE GNPCNMHLMD LSKIVRDSVA KAGFVPYRFN TIGVSDGISM
     GTKGMRYSLQ SREIIADSIE TVMNGQWYDG NISLPGCDKN MPGVAIAMGR VNRPSIMVYG
     GSIKPGCTKA GDPIDIVSAF QAYGQYITGD ISEEQRFDII RNACPGSGAC GGMYTANTMA
     SAIETMGPTL PGRRGCSDRE DIRPRDIMTR QAFENAMIIV SILGGSTNAV LHLIAIADSV
     GIKLTIDDFQ SVSDRIPLLA DLKPSGKYVM EDVHKIGGTP SLLKFLLKEG IIDGSGITVT
     GKTMKQNVEN VPSFPADQNI IRPLSNPIKS TGHIQILRGS LAPGGCVGKI TGKEGLRFTG
     RARVYDAEDD FIESLERNEI KKGDKTVVII RYDGPRGGPG MPEMLKPSSA IMGAGLGKDV
     ALITDGRFSG GSHGFIIGHV VPEAMLGGPI ALVEDGDEIV IDAEKRVLDL VIPEKEMERR
     RKAWKAPAPR YNKGTLKKYA SLVSDASSGC VTDGPI
//