ID T5AKB0_OPHSC Unreviewed; 1154 AA.
AC T5AKB0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:EQL02177.1};
GN ORFNames=OCS_02121 {ECO:0000313|EMBL:EQL02177.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02177.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL02177.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02177.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
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DR EMBL; KE652341; EQL02177.1; -; Genomic_DNA.
DR AlphaFoldDB; T5AKB0; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_8_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1068..1145
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1154 AA; 125482 MW; F872FBC1DD683F70 CRC64;
MASEYFTRFY KEANGAERNA RAFQRWFDLK AHKVPGLRVI EIGAGTASTT VPVLRRLGDG
ELSTPRLSKW TFTDISPGWF ENAKSLLSDW QPYVEYKVLD IEDDPVEQGF EAESYDVVLA
VNVLHATKDI QTTLRHCSRL LKPGGNLVLG EITNPTDLVS FVFGTLPGWW AAEDDRKGGP
LLLRHQWDET LKEAGFSGSD AAITDGDDGV AHRMSTLIST KPYRGDAVSA KNVTVVVPDD
CGEATQSLAS CICREFQSLG ARAAINSVGT AVADVEGKTV VSLLEYEESF LQDAQEAHFE
QVKHLVLYSA EVLWVTRSDV ADGPGHPSKR IVSGLLRCVK MEDATRRLYE MHLCREPAGD
VESVSGVVGR RLRGIWSRNE GVLEEMETSE RDGAFCIPRY MPDKTMNQSL ARATGSNVSP
EMTGLVQAGR PLRLTIGQPG ALETLHFVDE SLPQALAEDE VEMDVSACGL NFRDVLIAMG
ELQRPVLGHE AVGIVRRVGA KVTEFSPADR VICITPGVMQ TTVRVHESCV HHAPASLSDE
EAAPIPIAYA TAYQSLMEVA RLEKGESVLI HTAAGGLGQA LIQLAKMLEA DIFCTVSTEA
KKQAVVAMGV EPDHVFSSRD LSFERGIKRV THGRGVDVIV NSLAGEALQR SWMCLAPHGR
FVEVGIKDII GNSRLDMRPF LNNATFSAVN LEAMMRGSRQ GRKVVSSVLR LFEQGAIGPI
RPIVAHDFSN VEAAFREMQR GTHIGKLVLR FTPESRAPVR PPSFFSWSLD PNATYLLVGG
FGGLGRAQAT FMAEHGARHL VFISRSGAAR DEARLLVAKL AAAGVETKVY AADVADKKQL
KAILDEVSQT MPPIRGVIQG AMVLQDTLFH KMDYRQWAAA TKPKIQGYWN LHELLPRSLD
FFILLSSLAG IIGACSQANY AAGNTYQDAL VHFRQSKGLP ALSLNLGVIK GFGYVAEHDD
VAAGLSPFLT PSVDEAQFFH LLGCALAGTA NGDGPLTPQL LVGAGNGGAV QAMQRVSIDA
DFCWLSTLSP FAYLQRLGVQ TAEAAGNEPE TNYDRHLDRL RNSKSIDEAS ASVQELLLGK
IASIISIPTA DIDTAKPVYT YGVDSLVAVE LRNWLAKNLR SDLSIFELTS STPIHALTRK
IAARSRWLSA EAGS
//
