ID T5ALK6_OPHSC Unreviewed; 597 AA.
AC T5ALK6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=OCS_00979 {ECO:0000313|EMBL:EQL03301.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL03301.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL03301.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL03301.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE652219; EQL03301.1; -; Genomic_DNA.
DR AlphaFoldDB; T5ALK6; -.
DR eggNOG; ENOG502RYYW; Eukaryota.
DR HOGENOM; CLU_012943_2_2_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 2.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT REGION 446..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 597 AA; 66488 MW; BB2876A3990B1D6D CRC64;
MAARSASRSS SSSSCTLVDL VDVDDDAQNV FEDVVIDLTD DYSSSLLRDG ELALDRLQAR
GATWRPGDVV EVRGAHLGSY AVDFLKIKII AETRSGEHVI RGDPLVRTRA LLGKLLNKKN
EVCWLHFIED AGPIYLDISP QSIVRRRSLI ITNAPYPEHS LWSLATHSDN GISHGHGTRQ
EHDAEHFGPL ACRWRLTIYF ERKGRQMRPV EEALESMPST DVPDSRYHMP YDALRNRWHG
AIIAGGSWNA GRAAHVDLEA ASQAPRTRSH GQKYTFFDAF SGAGGASRGA QGAGFKVQYA
VDKSPEVWET YRGNFPQARL FKTCTHGFLT QTHGENIRVD VLHLSPPCQF FSPAHTHDSV
HDADNIAALF GCGELIKKTR PRIITLEQTF GITHDRHIRY FRALIGQMTQ HGYSVRWRVV
RLCTWGSAQD RKRLVVIAAS PGHRLPPFPA ATHSETGGGG ETGGGGRKPF TTISQAIDGI
PRGHDLHQVW RVHHFEPPRA PLDPHKLARP ITTGGAELYH PSGTRKLTLR ELASLQGFPL
HHRFVGNDTS IRKQIGNAFP PNTVDVLYRH LQRWLLQEDG IVPLRPNVAQ VLIVDDD
//
