ID   T5AM34_OPHSC            Unreviewed;       351 AA.
AC   T5AM34;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:EQL02817.1};
GN   ORFNames=OCS_01482 {ECO:0000313|EMBL:EQL02817.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL02817.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL02817.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL02817.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
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DR   EMBL; KE652264; EQL02817.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5AM34; -.
DR   eggNOG; KOG1196; Eukaryota.
DR   HOGENOM; CLU_026673_29_1_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT   DOMAIN          20..340
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   351 AA;  37808 MW;  840A06236B88E78A CRC64;
     MVPIKSLIFK KIPTGVPVPG EHLAVETRDT DLETPPPGGL IVEVLYASFD PYLRGRMRDP
     GVKSYVPAFE LGQPMTNGTV SRVVKSGSPD FAEGDLVTAS TAIAEYARIE RAVAPAVNKI
     RNPHRLPLGL FLGPLGMPGL TAWSGLHRIG RPQKGETIFG LTVIGSVGAD DKLDFITKEL
     GFDAGFNYHK EKPLDALRRL APQGVDIYFE NVGGDHLEAA LEVMNEGGRI AACGMISEYS
     IPQSKRKGIQ NLMNIVAKQI TMQGFINLMN IVAKQITMQG FIVNNPGFGP AHAKEPQEKL
     QEWLGDGSVK AKLHITDGID NGPEAFVGML QGENFGKAVL RVKGESAGSN N
//