ID   T5S2L2_9FIRM            Unreviewed;       385 AA.
AC   T5S2L2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=NlpC/P60 domain-containing protein {ECO:0000259|PROSITE:PS51935};
GN   ORFNames=HMPREF0866_04546 {ECO:0000313|EMBL:EQN61093.1};
OS   Ruminococcaceae bacterium D16.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX   NCBI_TaxID=552398 {ECO:0000313|EMBL:EQN61093.1, ECO:0000313|Proteomes:UP000002801};
RN   [1] {ECO:0000313|Proteomes:UP000002801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D16 {ECO:0000313|Proteomes:UP000002801};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA   Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA   Sibley C.D., White A.P., Crowley S., Surette M.G., Strauss J.C.,
RA   Ambrose C.E., Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium sp. D5.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EQN61093.1, ECO:0000313|Proteomes:UP000002801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D16 {ECO:0000313|EMBL:EQN61093.1,
RC   ECO:0000313|Proteomes:UP000002801};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., White A.P.,
RA   Crowley S., Surette M.G., Strauss J.C., Ambrose C.E., Allen-Vercoe E.,
RA   Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Ruminococcaceae bacterium D16.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C40 family.
CC       {ECO:0000256|ARBA:ARBA00007074}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQN61093.1}.
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DR   EMBL; ADDX02000001; EQN61093.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5S2L2; -.
DR   STRING; 552398.HMPREF0866_04546; -.
DR   HOGENOM; CLU_016043_12_1_9; -.
DR   Proteomes; UP000002801; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR   InterPro; IPR000064; NLP_P60_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR   PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR   Pfam; PF00877; NLPC_P60; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS51935; NLPC_P60; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002801};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        35..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          231..385
FT                   /note="NlpC/P60"
FT                   /evidence="ECO:0000259|PROSITE:PS51935"
SQ   SEQUENCE   385 AA;  40628 MW;  EBD6714B8CD1B472 CRC64;
     MTARQAAQAA NRALRAVIAA AKALAAAATA GGGVVIAVVI VICLCGIILA SPLGIFFAGP
     DETTGAISPA QAVAQINGEL GEKISSMQAE GGYDTLEIQG EPPPWSDILA VFAAKTAGAS
     DGTTVAILDA ANVEALRTVF WDMTKLTSSS REVEHPASGD TPAWTEQILT VTITARTPDD
     MRVFYSFTEE QNKALDELLA NSDMLAALAG DLTISDTTAK KLLADLPADL DPERRAVVET
     ACRLVGKVNY FWGGKSLAIG WDSRWGQLTK VWADGSSTTG TYLPYGLDCS GFVDWVFYNV
     TDGEYVIGHG GGAHMQHTYC TPISWNEAQP GDLVFYPGDE HVGIVGGRDE SGNLLIIHCA
     FSQNNVVITG LEGFTSIGRP LYYGA
//