ID TAGL_CHICK Reviewed; 200 AA.
AC P19966;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 142.
DE RecName: Full=Transgelin;
DE AltName: Full=Smooth muscle protein 22-alpha;
DE Short=SM22-alpha;
GN Name=TAGLN; Synonyms=SM22;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gizzard smooth muscle;
RX PubMed=1872880;
RA Nishida W., Kitami Y., Abe M., Kiwada K.;
RT "Gene cloning and nucleotide sequence of SM22 alpha from the chicken
RT gizzard smooth muscle.";
RL Biochem. Int. 23:663-668(1991).
RN [2]
RP PROTEIN SEQUENCE OF 2-198, AND ACETYLATION AT ALA-2.
RC TISSUE=Gizzard smooth muscle;
RX PubMed=3571244; DOI=10.1016/s0021-9258(18)45526-3;
RA Pearlstone J.R., Weber M., Lees-Miller J.P., Carpenter M.R., Smillie L.B.;
RT "Amino acid sequence of chicken gizzard smooth muscle SM22 alpha.";
RL J. Biol. Chem. 262:5985-5991(1987).
CC -!- FUNCTION: Actin cross-linking/gelling protein. {ECO:0000250}.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Gizzard, uterus, intestine, esophagus, aorta, and
CC trace amounts in brain, liver and heart.
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR EMBL; M83105; AAA48782.1; -; mRNA.
DR PIR; I50236; A26694.
DR RefSeq; NP_990825.1; NM_205494.1.
DR RefSeq; XP_015153456.1; XM_015297970.1.
DR AlphaFoldDB; P19966; -.
DR SMR; P19966; -.
DR STRING; 9031.ENSGALP00000019399; -.
DR iPTMnet; P19966; -.
DR PaxDb; 9031-ENSGALP00000019399; -.
DR GeneID; 396490; -.
DR KEGG; gga:396490; -.
DR CTD; 6876; -.
DR VEuPathDB; HostDB:geneid_396490; -.
DR eggNOG; KOG2046; Eukaryota.
DR HOGENOM; CLU_055232_1_0_1; -.
DR InParanoid; P19966; -.
DR OMA; ADECKRE; -.
DR OrthoDB; 11630at2759; -.
DR PhylomeDB; P19966; -.
DR PRO; PR:P19966; -.
DR Proteomes; UP000000539; Chromosome 24.
DR Bgee; ENSGALG00000011902; Expressed in colon and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd21279; CH_TAGLN; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR PANTHER; PTHR47385; CALPONIN; 1.
DR PANTHER; PTHR47385:SF16; TRANSGELIN; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR PRINTS; PR00890; TRANSGELIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Muscle protein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:3571244"
FT CHAIN 2..200
FT /note="Transgelin"
FT /id="PRO_0000204784"
FT DOMAIN 24..137
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 175..199
FT /note="Calponin-like"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:3571244"
SQ SEQUENCE 200 AA; 22315 MW; 8F6207336ED5AAC9 CRC64;
MANKGPAYGM SRDVQSKIEK KYDDELEDRL VEWIVAQCGS SVGRPDRGRL GFQVWLKNGI
VLSQLVNSLY PDGSKPVKIP DSPPTMVFKQ MEQIAQFLKA AEDYGVVKTD MFQTVDLFEA
KDMAAVQRTL VALGSLAVTK NDGHYHGDPN WFMKKAQEHK REFSESQLKE GKNIIGLQMG
TNKGASQAGM SYGRPRQIIS
//
