ID TATB_MYCTU Reviewed; 131 AA.
AC P9WG99; L0T7N2; O33220;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Sec-independent protein translocase protein TatB {ECO:0000255|HAMAP-Rule:MF_00237};
GN Name=tatB {ECO:0000255|HAMAP-Rule:MF_00237}; OrderedLocusNames=Rv1224;
GN ORFNames=MTCI61.07;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=H37Rv;
RX PubMed=16952959; DOI=10.1128/jb.00631-06;
RA Saint-Joanis B., Demangel C., Jackson M., Brodin P., Marsollier L.,
RA Boshoff H., Cole S.T.;
RT "Inactivation of Rv2525c, a substrate of the twin arginine translocation
RT (Tat) system of Mycobacterium tuberculosis, increases beta-lactam
RT susceptibility and virulence.";
RL J. Bacteriol. 188:6669-6679(2006).
CC -!- FUNCTION: Part of the twin-arginine translocation (Tat) system that
CC transports large folded proteins containing a characteristic twin-
CC arginine motif in their signal peptide across membranes. Together with
CC TatC, TatB is part of a receptor directly interacting with Tat signal
CC peptides. TatB may form an oligomeric binding site that transiently
CC accommodates folded Tat precursor proteins before their translocation.
CC {ECO:0000255|HAMAP-Rule:MF_00237}.
CC -!- SUBUNIT: The Tat system comprises two distinct complexes: a TatABC
CC complex, containing multiple copies of TatA, TatB and TatC subunits,
CC and a separate TatA complex, containing only TatA subunits. Substrates
CC initially bind to the TatABC complex, which probably triggers
CC association of the separate TatA complex to form the active translocon.
CC {ECO:0000255|HAMAP-Rule:MF_00237}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00237};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00237}.
CC -!- DISRUPTION PHENOTYPE: Essential for growth.
CC {ECO:0000269|PubMed:16952959}.
CC -!- SIMILARITY: Belongs to the TatB family. {ECO:0000255|HAMAP-
CC Rule:MF_00237}.
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DR EMBL; AL123456; CCP43980.1; -; Genomic_DNA.
DR PIR; C70508; C70508.
DR RefSeq; NP_215740.1; NC_000962.3.
DR RefSeq; WP_003898780.1; NZ_NVQJ01000039.1.
DR AlphaFoldDB; P9WG99; -.
DR SMR; P9WG99; -.
DR STRING; 83332.Rv1224; -.
DR PaxDb; 83332-Rv1224; -.
DR DNASU; 887143; -.
DR GeneID; 887143; -.
DR KEGG; mtu:Rv1224; -.
DR TubercuList; Rv1224; -.
DR eggNOG; COG1826; Bacteria.
DR InParanoid; P9WG99; -.
DR OrthoDB; 3267321at2; -.
DR PhylomeDB; P9WG99; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0033281; C:TAT protein transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043953; P:protein transport by the Tat complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.3310; -; 1.
DR HAMAP; MF_00237; TatB; 1.
DR InterPro; IPR003369; TatA/B/E.
DR InterPro; IPR018448; TatB.
DR NCBIfam; TIGR01410; tatB; 1.
DR Pfam; PF02416; TatA_B_E; 1.
DR PRINTS; PR01506; TATBPROTEIN.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..131
FT /note="Sec-independent protein translocase protein TatB"
FT /id="PRO_0000192661"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00237"
FT REGION 90..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 131 AA; 14114 MW; D9B13A66772D8AB6 CRC64;
MFANIGWWEM LVLVMVGLVV LGPERLPGAI RWAASALRQA RDYLSGVTSQ LREDIGPEFD
DLRGHLGELQ KLRGMTPRAA LTKHLLDGDD SLFTGDFDRP TPKKPDAAGS AGPDATEQIG
AGPIPFDSDA T
//
