ID   TBCC1_BOVIN             Reviewed;         557 AA.
AC   A4IF93;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   08-NOV-2023, entry version 63.
DE   RecName: Full=TBCC domain-containing protein 1;
GN   Name=TBCCD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of centrosome and Golgi
CC       apparatus positioning, with consequences on cell shape and cell
CC       migration. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}. Note=Localizes at the spindle midzone, midbody and basal
CC       bodies of primary and motile cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
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DR   EMBL; BC134464; AAI34465.1; -; mRNA.
DR   RefSeq; NP_001077199.1; NM_001083730.1.
DR   AlphaFoldDB; A4IF93; -.
DR   SMR; A4IF93; -.
DR   STRING; 9913.ENSBTAP00000004087; -.
DR   PaxDb; 9913-ENSBTAP00000004087; -.
DR   GeneID; 538314; -.
DR   KEGG; bta:538314; -.
DR   CTD; 55171; -.
DR   eggNOG; KOG4416; Eukaryota.
DR   InParanoid; A4IF93; -.
DR   OrthoDB; 3019544at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
DR   GO; GO:0051661; P:maintenance of centrosome location; ISS:UniProtKB.
DR   GO; GO:0051684; P:maintenance of Golgi location; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR036223; CAP_C_sf.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR039589; TBCC1.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR16052:SF0; TBCC DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR16052; UNCHARACTERIZED; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   SMART; SM00673; CARP; 2.
DR   SUPFAM; SSF69340; C-terminal domain of adenylylcyclase associated protein; 1.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..557
FT                   /note="TBCC domain-containing protein 1"
FT                   /id="PRO_0000304943"
FT   DOMAIN          290..435
FT                   /note="C-CAP/cofactor C-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
SQ   SEQUENCE   557 AA;  63420 MW;  710DD10DD2D3F1BA CRC64;
     MDQSRVLLWV KAEPFIVGAL QIPPPSKFSL HYLRKISTYV RTRTIEGGYP RLSWSTWRHI
     ACGKLQLAKD LAWLYFEMFD SLAMKTPEER LEWSEILSNC MSEDEVEKQR NQLSVDTLQF
     LLFLHIQQLN KVSLRTSLIG EEWPSPRHRA QSPDLTEKSS CHNKNWNDYS HQAFVCDHLS
     DLLELLLDPE QLTASFHSTH SSLVSREAVV ALSFLIEGTV SGARKIYPLY ELALWHPLHA
     ETGFSKASKT FSFYKLEAWL RTCLTGNPFG TSACLKSGKK LAWAHQVEGT TKRAKIACNT
     HVAPRMHRMV VMSQVYKQTL AKSSDTLVGA HVKIHRCNES FIYLLSPLRS VTIEKCRNST
     FVLGPVQTAL HLHSCDNVKV IAVCHRLSIS STTGCIFHIL TPTRPLILSG NQRVTFAPFH
     THYPMLEDHM ARTGLATVPN YWDNPMIVCR ENSSPSVFRL LPPCEFYVFI IPFEMEGDTT
     EIPGGLPSAY QKALSQRKKK IQVWQKTVKE ARLTKDQRKQ FQVLVENKFY EWLINTGHRQ
     QLDSLVPPAA GSKQAAG
//