ID TBD_CANLF Reviewed; 453 AA.
AC Q8HZV4;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Tubulin delta chain;
DE AltName: Full=Delta-tubulin;
GN Name=TUBD1; Synonyms=TUBD;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12047234; DOI=10.1046/j.1365-2052.2002.0831d.x;
RA Sidjanin D.J., Zangerl B., Johnson J.L., Xue F., Mellersh C.,
RA Ostrander E.A., Acland G.M., Aguirre G.D.;
RT "Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9.";
RL Anim. Genet. 33:161-162(2002).
CC -!- FUNCTION: Acts as a positive regulator of hedgehog signaling and
CC regulates ciliary function. {ECO:0000250|UniProtKB:Q9R1K7}.
CC -!- SUBUNIT: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
CC {ECO:0000250|UniProtKB:Q9R1K7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q9R1K7}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q9R1K7}. Note=Associated with centrioles. Both
CC cytoplasmic and nuclear. In the elongating spermatid it is associated
CC with the manchette, a specialized microtubule system present during
CC reshaping of the sperm head. {ECO:0000250|UniProtKB:Q9R1K7}.
CC -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR EMBL; AF416724; AAN32643.1; -; mRNA.
DR RefSeq; NP_001003024.1; NM_001003024.1.
DR RefSeq; XP_005624378.1; XM_005624321.2.
DR RefSeq; XP_013971935.1; XM_014116460.1.
DR AlphaFoldDB; Q8HZV4; -.
DR SMR; Q8HZV4; -.
DR STRING; 9615.ENSCAFP00000052240; -.
DR PaxDb; 9612-ENSCAFP00000033984; -.
DR Ensembl; ENSCAFT00000028018.5; ENSCAFP00000026060.3; ENSCAFG00000017668.6.
DR Ensembl; ENSCAFT00030008426.1; ENSCAFP00030007401.1; ENSCAFG00030004436.1.
DR Ensembl; ENSCAFT00040003000.1; ENSCAFP00040002593.1; ENSCAFG00040001537.1.
DR Ensembl; ENSCAFT00805037410; ENSCAFP00805029282; ENSCAFG00805020698.
DR Ensembl; ENSCAFT00845045938.1; ENSCAFP00845036064.1; ENSCAFG00845025976.1.
DR GeneID; 403546; -.
DR KEGG; cfa:403546; -.
DR CTD; 51174; -.
DR VEuPathDB; HostDB:ENSCAFG00845025976; -.
DR VGNC; VGNC:47992; TUBD1.
DR eggNOG; KOG1374; Eukaryota.
DR GeneTree; ENSGT00940000157069; -.
DR HOGENOM; CLU_015718_1_0_1; -.
DR InParanoid; Q8HZV4; -.
DR OMA; ACHPEYK; -.
DR OrthoDB; 5476360at2759; -.
DR TreeFam; TF329833; -.
DR Proteomes; UP000002254; Chromosome 9.
DR Proteomes; UP000694429; Chromosome 9.
DR Proteomes; UP000694542; Chromosome 9.
DR Proteomes; UP000805418; Chromosome 9.
DR Bgee; ENSCAFG00000017668; Expressed in saliva-secreting gland and 46 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR CDD; cd02189; delta_zeta_tubulin-like; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002967; Delta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF4; TUBULIN DELTA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR PRINTS; PR01224; DELTATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Developmental protein; GTP-binding; Microtubule; Nucleotide-binding;
KW Nucleus; Reference proteome.
FT CHAIN 1..453
FT /note="Tubulin delta chain"
FT /id="PRO_0000048483"
FT BINDING 143..149
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 453 AA; 50849 MW; F7A20397DFD9DF2A CRC64;
MSVVTVQLGQ CGNQIGFEVF DALYSDSHCP QGLCSERENE AYQASSKERF FSEEENGVSI
ARAVLVDMEP KVINQTLSKA AQSGQWKYAQ HSCFCQKEGS GNNWAYGYSV HGPRHEESIM
NLIQKEVEKC DSLSGFFIIM SMAGGTGSGL GAFVTQNLQD QYSNSLKMNQ IIWPYGTGEV
IVQNYNSVLT LSHLYRSSDA LLVHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ
PTYSVEGSCH YRRNPLGDLM ENLVPHPEFK MLGIRNIPQM SENSLTYSTF TWAGLLKHLR
QMLISNSKME EGINWQVRPP LPGLPTLGKV SLNRELHFNT SIANLVILRG KDVHSADLGG
FKDPALYTSW LEPIDAFNVW KTQRAFSKYE KSAALVSNSQ FLLKPLDTIV GKAWNMFASK
AYIHQYTKFG IEEEDFLDSF TLLEQVVASY CNL
//
