ID TEAC_HALED Reviewed; 427 AA.
AC E1VBK3; Q8VPB1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Ectoine TRAP transporter large permease protein TeaC;
GN Name=teaC; OrderedLocusNames=HELO_4276;
OS Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198
OS / 1H9).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=768066;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE,
RP AND GENE NAME.
RC STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9;
RX PubMed=12003950; DOI=10.1128/jb.184.11.3078-3085.2002;
RA Grammann K., Volke A., Kunte H.J.;
RT "New type of osmoregulated solute transporter identified in halophilic
RT members of the bacteria domain: TRAP transporter TeaABC mediates uptake of
RT ectoine and hydroxyectoine in Halomonas elongata DSM 2581(T).";
RL J. Bacteriol. 184:3078-3085(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9;
RX PubMed=20849449; DOI=10.1111/j.1462-2920.2010.02336.x;
RA Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G.,
RA Seitz H., Rampp M., Schuster S.C., Klenk H.P., Pfeiffer F., Oesterhelt D.,
RA Kunte H.J.;
RT "A blueprint of ectoine metabolism from the genome of the industrial
RT producer Halomonas elongata DSM 2581(T).";
RL Environ. Microbiol. 13:1973-1994(2011).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system TeaABC involved in the uptake of ectoine and
CC hydroxyectoine in response to osmotic upshock. Probably functions as a
CC recovery system for synthesized ectoine that leaks out of the cell.
CC {ECO:0000269|PubMed:12003950}.
CC -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC protein TeaA, and the two transmembrane proteins TeaB and TeaC.
CC {ECO:0000269|PubMed:12003950}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Deletion abolishes accumulation of ectoine from
CC the medium. {ECO:0000269|PubMed:12003950}.
CC -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY061646; AAL29686.1; -; Genomic_DNA.
DR EMBL; FN869568; CBV44160.1; -; Genomic_DNA.
DR RefSeq; WP_013334030.1; NC_014532.2.
DR AlphaFoldDB; E1VBK3; -.
DR SMR; E1VBK3; -.
DR STRING; 768066.HELO_4276; -.
DR TCDB; 2.A.56.1.11; the tripartite atp-independent periplasmic transporter (trap-t) family.
DR KEGG; hel:HELO_4276; -.
DR eggNOG; COG1593; Bacteria.
DR HOGENOM; CLU_019824_4_1_6; -.
DR OrthoDB; 9796052at2; -.
DR Proteomes; UP000008707; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR004681; TRAP_DctM.
DR NCBIfam; TIGR00786; dctM; 1.
DR PANTHER; PTHR33362; SIALIC ACID TRAP TRANSPORTER PERMEASE PROTEIN SIAT-RELATED; 1.
DR Pfam; PF06808; DctM; 1.
DR PIRSF; PIRSF006066; HI0050; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..427
FT /note="Ectoine TRAP transporter large permease protein
FT TeaC"
FT /id="PRO_0000428829"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 427 AA; 44955 MW; C0FFCC9D78809558 CRC64;
MTTIMVATMI GLLLLGFPMM IPLATASIIG FFMMFGGLGQ METLIQQLMA GIRPASLIAV
PMFILAADIM TRGQSANRLI NMVMAFIGHI KGGLAVSTAA SCTLFGAVSG STQATVVAVG
SPLRPRMLKA GYSDSFSLAL IINSSDIAFL IPPSIGMIIY GIISGTSIGE LFIAGIGPGL
MILVMFAIYC VIYAIVRGVP TEPKASWGER FSAVRLALWP LGFPVIIIGG IYGGIFSPTE
AAAACVLYAV LLEFVVFRSL KISDIYAIAK STGLITAVVF ILVAVGNSFS WIISFAQIPQ
AILEAVGINE AGPTGVLIAI CVAFFVACMF VDPIVVILVL TPVFAPAIEA TGLDPVLVGI
LITLQVAIGS ATPPFGCDIF TAIAIFKRPY LDVIKGTPPF IFMLVLAAAL LILFPQIALF
LRDLAFR
//
