ID TECPR_DROME Reviewed; 1350 AA.
AC Q9VWB0; D0Z772;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 164.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein;
DE AltName: Full=Peroxin-23 protein;
GN Name=Pex23; ORFNames=CG32226;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=21669930; DOI=10.1242/dmm.007419;
RA Mast F.D., Li J., Virk M.K., Hughes S.C., Simmonds A.J., Rachubinski R.A.;
RT "A Drosophila model for the Zellweger spectrum of peroxisome biogenesis
RT disorders.";
RL Dis. Model. Mech. 4:659-672(2011).
CC -!- FUNCTION: Involved in peroxisome biogenesis.
CC {ECO:0000269|PubMed:21669930}.
CC -!- SIMILARITY: Belongs to the TECPR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACZ54681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014296; AAF49038.2; -; Genomic_DNA.
DR EMBL; BT100319; ACZ54681.1; ALT_INIT; mRNA.
DR RefSeq; NP_730508.1; NM_168841.2.
DR AlphaFoldDB; Q9VWB0; -.
DR SMR; Q9VWB0; -.
DR BioGRID; 65492; 3.
DR IntAct; Q9VWB0; 4.
DR STRING; 7227.FBpp0074615; -.
DR PaxDb; 7227-FBpp0074615; -.
DR DNASU; 40229; -.
DR EnsemblMetazoa; FBtr0074846; FBpp0074615; FBgn0288469.
DR GeneID; 40229; -.
DR KEGG; dme:Dmel_CG32226; -.
DR UCSC; CG32226-RA; d. melanogaster.
DR AGR; FB:FBgn0288469; -.
DR CTD; 40229; -.
DR FlyBase; FBgn0288469; Pex23.
DR VEuPathDB; VectorBase:FBgn0288469; -.
DR eggNOG; KOG3587; Eukaryota.
DR eggNOG; KOG3669; Eukaryota.
DR GeneTree; ENSGT00510000047886; -.
DR HOGENOM; CLU_008303_0_0_1; -.
DR InParanoid; Q9VWB0; -.
DR OMA; CPMQISR; -.
DR OrthoDB; 66441at2759; -.
DR PhylomeDB; Q9VWB0; -.
DR BioGRID-ORCS; 40229; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40229; -.
DR PRO; PR:Q9VWB0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0052226; Expressed in second segment of antenna (Drosophila) and 24 other cell types or tissues.
DR Genevisible; Q9VWB0; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR CDD; cd00070; GLECT; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001079; Galectin_CRD.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR23250; DYSFERLIN-RELATED; 1.
DR PANTHER; PTHR23250:SF1; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR Pfam; PF06462; Hyd_WA; 6.
DR Pfam; PF06398; Pex24p; 1.
DR Pfam; PF19193; Tectonin; 1.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00908; Gal-bind_lectin; 1.
DR SMART; SM00276; GLECT; 1.
DR SMART; SM00706; TECPR; 8.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 2: Evidence at transcript level;
KW Lectin; Peroxisome biogenesis; Reference proteome; Repeat.
FT CHAIN 1..1350
FT /note="Tectonin beta-propeller repeat-containing protein"
FT /id="PRO_0000337065"
FT REPEAT 23..59
FT /note="TECPR 1"
FT REPEAT 233..271
FT /note="TECPR 2"
FT REPEAT 280..320
FT /note="TECPR 3"
FT REPEAT 336..371
FT /note="TECPR 4"
FT DOMAIN 816..955
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT REPEAT 966..1000
FT /note="TECPR 5"
FT REPEAT 1187..1223
FT /note="TECPR 6"
FT REPEAT 1232..1269
FT /note="TECPR 7"
FT REPEAT 1278..1322
FT /note="TECPR 8"
FT REGION 396..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1350 AA; 149486 MW; C90308E58320BD4B CRC64;
MPSFYLFAAS SEGRVYTLST NSGAWRELPY LGLEFKKICA VPNFLWAIGG DRQVYVHVHG
LDVPIRIREE SYENERWLPI EGFSKTLLPT DRYRYSSADG SVERGVDKIR LPSMAWQWDG
DWHLDLELDG QPLTEDGWMY ALDFPATYSA KKSWNSYVRR RKWVRYRRYA ALNSWCAVAP
LHKDPTQEPF IDVAIGGTCV PNAPAGTLCV WAITAHGRAM FRTGVSKTAP EGLRWTAVPT
PTGSELAQIS VGPTGLVWAV LHNGRVIVRT GVTRDNLVGD SWLDVKTPVA ASSLRIVHVS
VGTDAVWCVT NDHHAWFRRG VKGEAAGISE DSAIGKGWVE MVGNISMVSV AANDQVFAIG
AADRCLYHRS GVTSADPTGK KWRLIQCPMQ ISRTSSSLSI VSRKSGGSSS TPGSKHQSFS
NLYSKEKEKG VVETCAVIET VLNSSTGSCS SNGGPPGLLK NERWKLSADS PPTIGSLNLN
DRHKQRTAAL RETSHASSAP AADVVEVVTG KFETQLRNPR AWSPVRSVGS VVGTEAHPES
DSTVFESDST HHGSDVFLGE DDDHTGSQFW TECGILWSCV ASGAVTVDAS NMPNWFNEQT
SDSKVDVNAN WRKDIVNKLQ RRQEKLAKLQ TVAKFEKAVE LSSWVKSADA RYQRPGGEFE
DCIIELEWVS SGSGTDTNSS ENSRSGDSGT FTVLSPDGAA TKIQFPLSDI TCVQCCSEAG
APRIAIHAPH LPVNCSPVKL QFSSDSEMED WLSHLSSVCS QINTMVGKPA GNAIWITSEL
GDVFVFDPAN MKAHQTSEPS EGYVEKMDVS TCETPYYNTL YNGMPCGTEL EISGCVYDDA
DQIRFDLQSH SAVKVQPHRV EKHRVIALHL NPRFNERTTV LNSMKESEWL DEIRNDKMAF
APGATFSLKI RALQDHYLII VNNAVYTDYK YRIDPESVTR LYVSGRIKLF NVLYRCPSLI
VSMERMHWRQ MGGHIKRIFN SGVDVVWGIS CDNTGWVYNG GWGGMFLKGL EGSGKINPMI
DTHTYYVYEN QRWNPISGFT AKSLPTDRHM WSDATGRQKR SKEHTKLLST HCEWISDWAI
DYNIPGGADK EGWQYAIDFP ANYHAHKKLT DCVRRRRWMK RCRLSSSGPW QELSQSKILD
AALQVLDEDV DHSCSGERNT AVAAWAIASN GDVLIRHGVC SLNPRGDAWE HITSDQPLVG
ISVGPTGQVW TVARNGMVFF RYGISRQNPC GDAWQQVEAP AGVTFKAISV GRAGIWALDN
QQRLAVRKEI SRTFPEGSHW QFLPNAANVP PHTDQHCGFR SVSVGSEVWA ISLNGIICRR
CGITEENPAG VGWNLGIAGQ WQNVSVEGYM
//
