GenomeNet

Database: UniProt
Entry: TEDC1_MOUSE
LinkDB: TEDC1_MOUSE
Original site: TEDC1_MOUSE 
ID   TEDC1_MOUSE             Reviewed;         420 AA.
AC   Q3UK37; E9Q930; Q3TK97;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   17-JUN-2020, entry version 83.
DE   RecName: Full=Tubulin epsilon and delta complex protein 1 {ECO:0000303|PubMed:29459677};
DE   AltName: Full=Uncharacterized protein C14orf80 homolog;
GN   Name=Tedc1 {ECO:0000312|MGI:MGI:2144738};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and DBA/2J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH TEDC2, SUBUNIT, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA   Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA   Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA   Nachury M.V.;
RT   "A CRISPR-based screen for Hedgehog signaling provides insights into
RT   ciliary function and ciliopathies.";
RL   Nat. Genet. 50:460-471(2018).
CC   -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC       Required for centriole stability (PubMed:29459677). May play a role in
CC       counteracting perturbation of actin filaments, such as after treatment
CC       with the actin depolymerizing microbial metabolite Chivosazole F (By
CC       similarity). {ECO:0000250|UniProtKB:Q86SX3,
CC       ECO:0000269|PubMed:29459677}.
CC   -!- SUBUNIT: Interacts with TEDC2 (PubMed:29459677). Found in a complex
CC       with TEDC1, TEDC2, TUBE1 and TUBD1 (PubMed:29459677).
CC       {ECO:0000269|PubMed:29459677}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000269|PubMed:29459677}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000269|PubMed:29459677}.
DR   EMBL; AK146189; BAE26965.1; -; mRNA.
DR   EMBL; AK167092; BAE39248.1; -; mRNA.
DR   EMBL; AC161112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS49196.1; -.
DR   RefSeq; NP_598802.2; NM_134041.3.
DR   SMR; Q3UK37; -.
DR   BioGRID; 222690; 1.
DR   STRING; 10090.ENSMUSP00000035351; -.
DR   iPTMnet; Q3UK37; -.
DR   PhosphoSitePlus; Q3UK37; -.
DR   PaxDb; Q3UK37; -.
DR   PRIDE; Q3UK37; -.
DR   Antibodypedia; 48308; 51 antibodies.
DR   Ensembl; ENSMUST00000049271; ENSMUSP00000035351; ENSMUSG00000037466.
DR   GeneID; 104732; -.
DR   KEGG; mmu:104732; -.
DR   UCSC; uc007pga.2; mouse.
DR   CTD; 283643; -.
DR   MGI; MGI:2144738; Tedc1.
DR   eggNOG; ENOG410IWUX; Eukaryota.
DR   eggNOG; ENOG4111XJF; LUCA.
DR   GeneTree; ENSGT00390000011474; -.
DR   HOGENOM; CLU_052124_0_0_1; -.
DR   InParanoid; Q3UK37; -.
DR   OMA; SCTPGMG; -.
DR   OrthoDB; 1248596at2759; -.
DR   TreeFam; TF330945; -.
DR   BioGRID-ORCS; 104732; 5 hits in 12 CRISPR screens.
DR   ChiTaRS; Tedc1; mouse.
DR   PRO; PR:Q3UK37; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q3UK37; protein.
DR   Bgee; ENSMUSG00000037466; Expressed in humerus cartilage element and 142 other tissues.
DR   ExpressionAtlas; Q3UK37; baseline and differential.
DR   Genevisible; Q3UK37; MM.
DR   GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR   GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR   InterPro; IPR027996; DUF4509.
DR   InterPro; IPR028100; DUF4510.
DR   Pfam; PF14970; DUF4509; 1.
DR   Pfam; PF14971; DUF4510; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..420
FT                   /note="Tubulin epsilon and delta complex protein 1"
FT                   /id="PRO_0000330693"
FT   COILED          276..340
FT                   /evidence="ECO:0000255"
FT   COILED          377..409
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        2..7
FT                   /note="Poly-Arg"
FT   CONFLICT        34
FT                   /note="I -> V (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        146
FT                   /note="P -> L (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="E -> K (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        201
FT                   /note="Q -> R (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        229
FT                   /note="S -> G (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260
FT                   /note="P -> H (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="F -> V (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274
FT                   /note="E -> A (in Ref. 1; BAE26965)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   420 AA;  46797 MW;  69C309A2DCEBD66E CRC64;
     MRRRRSRVEG AARALPEAVA ALSRCLPAGP SPEIFRRAKF DRPEAAPVLW QLLLRVLSPL
     AANNTWTDLA PEAQACVVKS ALGSQGYPRS VLLQFPDGSS QGSRELLLAL SWLLARGPLL
     EQLLAQTRVQ LGDQLPQWEA PTSPGPPAPF VEPKSPVDLR LVEWLMGRLR FRWRCLISSQ
     QEQCILLSKI HLYTQGCHSQ QSLGHLSVAE TEMLRDPESG QQLLQALESE NIRLEAALEW
     RRRELVFWQW MDTVLDTCSP ETPAVTSQPT FLPEISEGGL GELESVKQEL QALQEELREV
     SEPRRAAWEA RVGGLGQGPE WSNSRKALQE AVQQELAALQ GSWEQSSTPG QPQRPHRLVR
     SKDGAPRPQG LQAAEVIRTL SAKEACLKKA LHQLQRQCQQ ELARLAGALP GLIWILPPEH
//
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