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Database: UniProt
Entry: TEN4_HUMAN
LinkDB: TEN4_HUMAN
Original site: TEN4_HUMAN 
ID   TEN4_HUMAN              Reviewed;        2769 AA.
AC   Q6N022; A6ND26; Q7Z3C7; Q96MS6; Q9P2P4; Q9Y4S2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   24-JAN-2024, entry version 156.
DE   RecName: Full=Teneurin-4;
DE            Short=Ten-4;
DE   AltName: Full=Protein Odd Oz/ten-m homolog 4;
DE   AltName: Full=Tenascin-M4;
DE            Short=Ten-m4;
DE   AltName: Full=Teneurin transmembrane protein 4;
GN   Name=TENM4; Synonyms=KIAA1302, ODZ4, TNM4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-2769.
RC   TISSUE=Brain;
RX   PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVI. The
RT   complete sequences of 150 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:65-73(2000).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1371-2769.
RC   TISSUE=Brain, Cervix, and Fetal kidney;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2040-2715.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [7]
RP   FUNCTION, SUBCELLULAR LOCATION, INVOLVEMENT IN ETM5, VARIANTS ETM5 PRO-53;
RP   ASP-474; GLN-518; MET-1128; MET-1138; ASN-1367; THR-1442; GLN-1535;
RP   HIS-1632; ARG-1763 AND ILE-2451, AND CHARACTERIZATION OF VARIANTS ETM5
RP   MET-1138; ASN-1367 AND THR-1442.
RX   PubMed=26188006; DOI=10.1093/hmg/ddv281;
RA   Hor H., Francescatto L., Bartesaghi L., Ortega-Cubero S., Kousi M.,
RA   Lorenzo-Betancor O., Jimenez-Jimenez F.J., Gironell A., Clarimon J.,
RA   Drechsel O., Agundez J.A., Kenzelmann Broz D., Chiquet-Ehrismann R.,
RA   Lleo A., Coria F., Garcia-Martin E., Alonso-Navarro H., Marti M.J.,
RA   Kulisevsky J., Hor C.N., Ossowski S., Chrast R., Katsanis N., Pastor P.,
RA   Estivill X.;
RT   "Missense mutations in TENM4, a regulator of axon guidance and central
RT   myelination, cause essential tremor.";
RL   Hum. Mol. Genet. 24:5677-5686(2015).
RN   [8]
RP   VARIANT GLU-519.
RX   PubMed=30976112; DOI=10.1038/s41431-019-0380-y;
RA   Harel T., Levy-Lahad E., Daana M., Mechoulam H., Horowitz-Cederboim S.,
RA   Gur M., Meiner V., Elpeleg O.;
RT   "Homozygous stop-gain variant in LRRC32, encoding a TGFbeta receptor,
RT   associated with cleft palate, proliferative retinopathy, and developmental
RT   delay.";
RL   Eur. J. Hum. Genet. 27:1315-1319(2019).
CC   -!- FUNCTION: Involved in neural development, regulating the establishment
CC       of proper connectivity within the nervous system. Plays a role in the
CC       establishment of the anterior-posterior axis during gastrulation.
CC       Regulates the differentiation and cellular process formation of
CC       oligodendrocytes and myelination of small-diameter axons in the central
CC       nervous system (CNS) (PubMed:26188006). Promotes activation of focal
CC       adhesion kinase. May function as a cellular signal transducer (By
CC       similarity). {ECO:0000250|UniProtKB:Q3UHK6,
CC       ECO:0000269|PubMed:26188006}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked (Probable). May also form
CC       heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).
CC       {ECO:0000250, ECO:0000305}.
CC   -!- INTERACTION:
CC       Q6N022; Q92608: DOCK2; NbExp=3; IntAct=EBI-12827077, EBI-448771;
CC       Q6N022; P17482: HOXB9; NbExp=3; IntAct=EBI-12827077, EBI-745290;
CC       Q6N022; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-12827077, EBI-6658837;
CC       Q6N022; P56470: LGALS4; NbExp=3; IntAct=EBI-12827077, EBI-720805;
CC       Q6N022; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12827077, EBI-769257;
CC       Q6N022; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-12827077, EBI-11955083;
CC       Q6N022; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12827077, EBI-6427977;
CC       Q6N022; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-12827077, EBI-11090299;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26188006};
CC       Single-pass membrane protein {ECO:0000255}. Cell projection
CC       {ECO:0000250|UniProtKB:Q3UHK6}. Nucleus {ECO:0000250|UniProtKB:Q3UHK6}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q3UHK6}.
CC   -!- DOMAIN: EGF-like domains 2 and 5 which have an odd number of cysteines
CC       might enable the formation of intermolecular disulfide bonds.
CC   -!- DOMAIN: Cytoplasmic proline-rich regions could serve as docking domains
CC       for intracellular SH3-containing proteins.
CC   -!- DISEASE: Tremor, hereditary essential 5 (ETM5) [MIM:616736]: A common
CC       movement disorder mainly characterized by postural tremor of the arms.
CC       Head, legs, trunk, voice, jaw, and facial muscles may also be involved.
CC       The condition can be aggravated by emotions, hunger, fatigue and
CC       temperature extremes, and may cause a functional disability or even
CC       incapacitation. Inheritance is autosomal dominant.
CC       {ECO:0000269|PubMed:26188006}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71206.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AP002515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB037723; BAA92540.3; -; mRNA.
DR   EMBL; BX640737; CAE45850.1; -; mRNA.
DR   EMBL; AL080120; CAB45719.1; -; mRNA.
DR   EMBL; BX537983; CAD97943.1; -; mRNA.
DR   EMBL; AK056531; BAB71206.1; ALT_INIT; mRNA.
DR   CCDS; CCDS44688.1; -.
DR   PIR; T12457; T12457.
DR   RefSeq; NP_001092286.2; NM_001098816.2.
DR   RefSeq; XP_016873015.1; XM_017017526.1.
DR   PDB; 7BAM; EM; 3.50 A; A/B=834-2765.
DR   PDB; 7BAN; EM; 2.70 A; A/B=834-2765.
DR   PDB; 7BAO; EM; 2.70 A; A=834-2765.
DR   PDB; 7PLP; X-ray; 1.40 A; A/B=833-871.
DR   PDBsum; 7BAM; -.
DR   PDBsum; 7BAN; -.
DR   PDBsum; 7BAO; -.
DR   PDBsum; 7PLP; -.
DR   EMDB; EMD-12124; -.
DR   EMDB; EMD-12125; -.
DR   EMDB; EMD-12126; -.
DR   SASBDB; Q6N022; -.
DR   SMR; Q6N022; -.
DR   BioGRID; 117484; 18.
DR   IntAct; Q6N022; 10.
DR   STRING; 9606.ENSP00000278550; -.
DR   CarbonylDB; Q6N022; -.
DR   GlyCosmos; Q6N022; 13 sites, 1 glycan.
DR   GlyGen; Q6N022; 14 sites, 2 O-linked glycans (2 sites).
DR   iPTMnet; Q6N022; -.
DR   PhosphoSitePlus; Q6N022; -.
DR   SwissPalm; Q6N022; -.
DR   BioMuta; TENM4; -.
DR   DMDM; 117949795; -.
DR   jPOST; Q6N022; -.
DR   MassIVE; Q6N022; -.
DR   MaxQB; Q6N022; -.
DR   PaxDb; 9606-ENSP00000278550; -.
DR   PeptideAtlas; Q6N022; -.
DR   ProteomicsDB; 66601; -.
DR   Antibodypedia; 67208; 27 antibodies from 7 providers.
DR   DNASU; 26011; -.
DR   Ensembl; ENST00000278550.12; ENSP00000278550.7; ENSG00000149256.16.
DR   GeneID; 26011; -.
DR   KEGG; hsa:26011; -.
DR   MANE-Select; ENST00000278550.12; ENSP00000278550.7; NM_001098816.3; NP_001092286.2.
DR   UCSC; uc001ozl.5; human.
DR   AGR; HGNC:29945; -.
DR   CTD; 26011; -.
DR   DisGeNET; 26011; -.
DR   GeneCards; TENM4; -.
DR   HGNC; HGNC:29945; TENM4.
DR   HPA; ENSG00000149256; Tissue enhanced (ovary, parathyroid gland).
DR   MalaCards; TENM4; -.
DR   MIM; 610084; gene.
DR   MIM; 616736; phenotype.
DR   neXtProt; NX_Q6N022; -.
DR   OpenTargets; ENSG00000149256; -.
DR   Orphanet; 862; NON RARE IN EUROPE: Hereditary essential tremor.
DR   PharmGKB; PA134896466; -.
DR   VEuPathDB; HostDB:ENSG00000149256; -.
DR   eggNOG; KOG4659; Eukaryota.
DR   GeneTree; ENSGT01030000234566; -.
DR   HOGENOM; CLU_000229_0_0_1; -.
DR   InParanoid; Q6N022; -.
DR   OMA; TQYFYAN; -.
DR   OrthoDB; 5491728at2759; -.
DR   PhylomeDB; Q6N022; -.
DR   TreeFam; TF316833; -.
DR   PathwayCommons; Q6N022; -.
DR   SignaLink; Q6N022; -.
DR   BioGRID-ORCS; 26011; 15 hits in 1144 CRISPR screens.
DR   ChiTaRS; TENM4; human.
DR   GeneWiki; ODZ4; -.
DR   GenomeRNAi; 26011; -.
DR   Pharos; Q6N022; Tbio.
DR   PRO; PR:Q6N022; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6N022; Protein.
DR   Bgee; ENSG00000149256; Expressed in hair follicle and 156 other cell types or tissues.
DR   ExpressionAtlas; Q6N022; baseline and differential.
DR   Genevisible; Q6N022; HS.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0060912; P:cardiac cell fate specification; IEA:Ensembl.
DR   GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0032289; P:central nervous system myelin formation; IMP:UniProtKB.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
DR   GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IMP:UniProtKB.
DR   GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR   GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR   GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0031641; P:regulation of myelination; IMP:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 1.
DR   Gene3D; 2.10.25.10; Laminin; 7.
DR   Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR022385; Rhs_assc_core.
DR   InterPro; IPR031325; RHS_repeat.
DR   InterPro; IPR009471; Ten_N.
DR   InterPro; IPR028916; Tox-GHH_dom.
DR   InterPro; IPR006530; YD.
DR   NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR   NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR   PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR   Pfam; PF07974; EGF_2; 2.
DR   Pfam; PF05593; RHS_repeat; 1.
DR   Pfam; PF06484; Ten_N; 2.
DR   Pfam; PF15636; Tox-GHH; 1.
DR   SMART; SM00181; EGF; 8.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
DR   PROSITE; PS00022; EGF_1; 8.
DR   PROSITE; PS01186; EGF_2; 7.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS51361; TENEURIN_N; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Cell projection; Cytoplasm;
KW   Developmental protein; Differentiation; Disease variant; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..2769
FT                   /note="Teneurin-4"
FT                   /id="PRO_0000259508"
FT   TOPO_DOM        1..345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        367..2769
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..341
FT                   /note="Teneurin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00694"
FT   DOMAIN          562..593
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          594..624
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          626..658
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          659..690
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          692..725
FT                   /note="EGF-like 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          726..757
FT                   /note="EGF-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          758..787
FT                   /note="EGF-like 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          788..831
FT                   /note="EGF-like 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          1216..1259
FT                   /note="NHL 1"
FT   REPEAT          1264..1308
FT                   /note="NHL 2"
FT   REPEAT          1334..1378
FT                   /note="NHL 3"
FT   REPEAT          1393..1444
FT                   /note="NHL 4"
FT   REPEAT          1523..1566
FT                   /note="NHL 5"
FT   REPEAT          1576..1595
FT                   /note="YD 1"
FT   REPEAT          1612..1632
FT                   /note="YD 2"
FT   REPEAT          1675..1694
FT                   /note="YD 3"
FT   REPEAT          1695..1717
FT                   /note="YD 4"
FT   REPEAT          1887..1906
FT                   /note="YD 5"
FT   REPEAT          1928..1946
FT                   /note="YD 6"
FT   REPEAT          1947..1967
FT                   /note="YD 7"
FT   REPEAT          1974..1991
FT                   /note="YD 8"
FT   REPEAT          1992..2013
FT                   /note="YD 9"
FT   REPEAT          2014..2031
FT                   /note="YD 10"
FT   REPEAT          2034..2054
FT                   /note="YD 11"
FT   REPEAT          2057..2077
FT                   /note="YD 12"
FT   REPEAT          2085..2104
FT                   /note="YD 13"
FT   REPEAT          2110..2127
FT                   /note="YD 14"
FT   REPEAT          2128..2154
FT                   /note="YD 15"
FT   REPEAT          2156..2169
FT                   /note="YD 16"
FT   REPEAT          2170..2193
FT                   /note="YD 17"
FT   REPEAT          2196..2216
FT                   /note="YD 18"
FT   REPEAT          2217..2237
FT                   /note="YD 19"
FT   REPEAT          2239..2259
FT                   /note="YD 20"
FT   REPEAT          2271..2291
FT                   /note="YD 21"
FT   REPEAT          2293..2313
FT                   /note="YD 22"
FT   REPEAT          2339..2380
FT                   /note="YD 23"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..526
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         124
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHK6"
FT   MOD_RES         178
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHK6"
FT   CARBOHYD        467
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        940
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1259
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1609
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1705
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1741
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1799
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1884
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1985
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2328
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2646
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        566..576
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        570..581
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        583..592
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        601..612
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        614..623
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        630..641
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        635..646
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        648..657
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        662..673
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        667..678
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        680..689
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        700..713
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        715..724
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        729..739
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        733..744
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        746..755
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        760..770
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        764..775
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        777..786
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        800..810
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        804..819
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        821..830
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   VARIANT         14
FT                   /note="R -> Q (in dbSNP:rs58537389)"
FT                   /id="VAR_062167"
FT   VARIANT         53
FT                   /note="R -> P (in ETM5; uncertain significance;
FT                   dbSNP:rs760852624)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076654"
FT   VARIANT         396
FT                   /note="V -> I (in dbSNP:rs3812723)"
FT                   /id="VAR_060130"
FT   VARIANT         474
FT                   /note="A -> D (in ETM5; uncertain significance)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076655"
FT   VARIANT         506
FT                   /note="E -> Q (in dbSNP:rs17137261)"
FT                   /id="VAR_060131"
FT   VARIANT         518
FT                   /note="R -> Q (in ETM5; uncertain significance;
FT                   dbSNP:rs201191369)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076656"
FT   VARIANT         519
FT                   /note="G -> E (found in a patiend with developmental delay,
FT                   cleft palate and proliferative retinopathy; uncertain
FT                   significance; dbSNP:rs1591072819)"
FT                   /evidence="ECO:0000269|PubMed:30976112"
FT                   /id="VAR_085138"
FT   VARIANT         1128
FT                   /note="V -> M (in ETM5; uncertain significance;
FT                   dbSNP:rs556858741)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076657"
FT   VARIANT         1138
FT                   /note="V -> M (in ETM5; dominant negative effect on central
FT                   nervous myelination and axon guidance; changed localization
FT                   to the plasma membrane; clustered plasma membrane
FT                   localization; dbSNP:rs538881762)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076521"
FT   VARIANT         1367
FT                   /note="T -> N (in ETM5; dominant negative effect on central
FT                   nervous myelination and axon guidance; changed localization
FT                   to the plasma membrane; clustered plasma membrane
FT                   localization; dbSNP:rs763485258)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076522"
FT   VARIANT         1442
FT                   /note="A -> T (in ETM5; dominant negative effect on central
FT                   nervous myelination and axon guidance; changed localization
FT                   to the plasma membrane; clustered plasma membrane
FT                   localization; dbSNP:rs375681722)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076523"
FT   VARIANT         1535
FT                   /note="K -> Q (in ETM5; uncertain significance;
FT                   dbSNP:rs770111861)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076658"
FT   VARIANT         1632
FT                   /note="R -> H (in ETM5; uncertain significance;
FT                   dbSNP:rs199687168)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076659"
FT   VARIANT         1763
FT                   /note="G -> R (in ETM5; uncertain significance;
FT                   dbSNP:rs201995608)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076660"
FT   VARIANT         2451
FT                   /note="M -> I (in ETM5; uncertain significance;
FT                   dbSNP:rs201769315)"
FT                   /evidence="ECO:0000269|PubMed:26188006"
FT                   /id="VAR_076661"
FT   CONFLICT        1471
FT                   /note="T -> I (in Ref. 4; CAE45850)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1842
FT                   /note="D -> G (in Ref. 4; CAD97943)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2024
FT                   /note="L -> F (in Ref. 4; CAD97943)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2393
FT                   /note="N -> D (in Ref. 4; CAE45850)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2551
FT                   /note="Q -> L (in Ref. 5; BAB71206)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2586
FT                   /note="V -> G (in Ref. 4; CAB45719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2599
FT                   /note="N -> D (in Ref. 4; CAB45719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2657
FT                   /note="N -> S (in Ref. 5; BAB71206)"
FT                   /evidence="ECO:0000305"
FT   STRAND          839..842
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   STRAND          846..848
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   HELIX           851..853
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   HELIX           855..859
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   TURN            861..865
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   HELIX           867..870
FT                   /evidence="ECO:0007829|PDB:7PLP"
FT   HELIX           875..880
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           895..899
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          906..909
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          911..913
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          921..929
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          931..933
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          940..945
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           947..949
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          951..953
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          958..968
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          971..975
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          982..985
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          990..995
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1006..1009
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1022..1025
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1036..1038
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1040..1042
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1043..1046
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1047..1053
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1055..1058
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1060..1064
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1073..1078
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1088..1097
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1100..1107
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1113..1118
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1129..1144
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1150..1159
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1171..1173
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1178..1180
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1181..1184
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1185..1187
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1193..1195
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1196..1198
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1221..1224
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1235..1237
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1243..1246
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1248..1254
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1258..1265
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1272..1275
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1277..1279
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1283..1285
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1287..1289
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1292..1294
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1297..1305
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1314..1316
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1319..1323
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1336..1339
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1350..1355
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1361..1365
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1374..1377
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1401..1403
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1411..1415
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1416..1419
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1420..1424
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1429..1432
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1436..1442
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1462..1464
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1469..1475
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1481..1486
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1488..1490
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1492..1497
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1499..1501
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1503..1507
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1515..1517
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1519..1521
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1531..1533
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1539..1544
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1550..1554
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1555..1558
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1559..1564
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1572..1574
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1576..1580
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1581..1584
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1585..1589
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1595..1600
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1601..1603
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1606..1613
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1614..1616
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1617..1623
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1628..1633
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1635..1637
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1639..1643
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1649..1654
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           1656..1658
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1660..1664
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1669..1676
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1677..1680
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1681..1686
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1692..1697
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1703..1707
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1713..1729
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1736..1742
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1744..1753
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1756..1763
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1768..1771
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1777..1780
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1782..1784
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1793..1795
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1797..1801
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1803..1806
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1808..1819
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1821..1833
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1836..1844
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            1845..1848
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1849..1854
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1860..1865
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1871..1877
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1883..1887
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1893..1898
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1901..1907
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1913..1918
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1923..1929
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1932..1936
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1942..1947
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1953..1957
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1959..1961
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1963..1970
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1972..1980
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1982..1985
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1988..1992
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          1998..2003
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2004..2007
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2008..2014
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2020..2024
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2029..2034
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2036..2038
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2041..2047
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2052..2060
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2063..2071
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2079..2085
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2087..2098
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2106..2110
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2112..2114
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2117..2120
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2123..2127
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2132..2135
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2137..2145
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2149..2158
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2161..2170
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2176..2186
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2190..2196
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2202..2209
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2211..2214
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2219..2221
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2223..2226
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2235..2239
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2245..2248
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2251..2255
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2261..2264
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2267..2271
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2277..2282
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2288..2293
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2299..2307
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2310..2313
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2317..2319
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2325..2328
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2329..2332
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2333..2339
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2345..2350
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2355..2360
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2366..2371
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2376..2382
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2388..2392
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2402..2404
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2405..2408
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2409..2412
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2413..2415
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2417..2422
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2423..2426
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2427..2430
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2435..2437
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2453..2455
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2466..2469
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2472..2478
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2482..2484
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2501..2505
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2507..2510
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2511..2514
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2521..2532
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2540..2542
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2570..2583
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2589..2598
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2609..2611
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2614..2621
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2626..2631
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2635..2640
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2646..2653
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2662..2670
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2673..2680
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2683..2711
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2722..2730
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2737..2743
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   TURN            2745..2747
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2749..2751
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   HELIX           2755..2757
FT                   /evidence="ECO:0007829|PDB:7BAN"
FT   STRAND          2758..2763
FT                   /evidence="ECO:0007829|PDB:7BAN"
SQ   SEQUENCE   2769 AA;  307957 MW;  280D87D43FBE88A1 CRC64;
     MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV
     KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD
     TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP
     PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL
     LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS
     PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF
     VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK
     PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG
     RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH
     LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL
     CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV
     DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT GLCSCDPSWT
     GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG
     WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD
     SKDNDGDGLV DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF
     LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF
     DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN
     PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT
     HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY
     EYESCPDLIL WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP
     PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV
     TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV
     VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST
     LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI
     VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS
     GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI
     RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL
     ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG
     LLATKSNENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT
     NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV
     TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT
     LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD
     GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ
     PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM
     LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE
     TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR
     SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN
     GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA
     YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD
     LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII
     GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN
     SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL
     GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSGSVFGKGV KFALKDGRVT
     TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT
     LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR
     QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF
     MRQSEMGRR
//
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