ID TF2AA_DICDI Reviewed; 310 AA.
AC Q54G80;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 103.
DE RecName: Full=Transcription initiation factor IIA subunit 1;
DE AltName: Full=General transcription factor IIA subunit 1;
GN Name=gtf2a1; Synonyms=tfiial; ORFNames=DDB_G0290327;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC polymerase II and plays an important role in transcriptional
CC activation. TFIIA in a complex with tbp mediates transcriptional
CC activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: TFIIA is a heterodimer of the large subunit 1 and a small
CC subunit gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000162; EAL62290.1; -; Genomic_DNA.
DR RefSeq; XP_635803.1; XM_630711.1.
DR AlphaFoldDB; Q54G80; -.
DR SMR; Q54G80; -.
DR STRING; 44689.Q54G80; -.
DR PaxDb; 44689-DDB0216284; -.
DR EnsemblProtists; EAL62290; EAL62290; DDB_G0290327.
DR GeneID; 8627608; -.
DR KEGG; ddi:DDB_G0290327; -.
DR dictyBase; DDB_G0290327; gtf2a1.
DR eggNOG; KOG2652; Eukaryota.
DR HOGENOM; CLU_030027_0_0_1; -.
DR InParanoid; Q54G80; -.
DR OMA; VLCQYEK; -.
DR Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-DDI-9018519; Estrogen-dependent gene expression.
DR PRO; PR:Q54G80; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005672; C:transcription factor TFIIA complex; ISS:dictyBase.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; ISS:dictyBase.
DR CDD; cd07976; TFIIA_alpha_beta_like; 1.
DR Gene3D; 1.10.287.100; -; 1.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR004855; TFIIA_asu/bsu.
DR InterPro; IPR009088; TFIIA_b-brl.
DR PANTHER; PTHR12694; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1; 1.
DR PANTHER; PTHR12694:SF8; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1; 1.
DR Pfam; PF03153; TFIIA; 1.
DR SMART; SM01371; TFIIA; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Transcription initiation factor IIA subunit 1"
FT /id="PRO_0000328131"
FT REGION 52..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34518 MW; E9E5D5FD35B69203 CRC64;
MSVDSVYKYI VFDVIRNIKS NIKNDSDTEN VDESIIDEIQ TMWLDRLTQT GAISNQNDPD
ETTATTTTTQ PQSTLSTVEH ENVRNTLNSL IQLNNKSQTT TTTTTSTFGN PQQYLPPQKE
VSNGTSPTMN SSNGSNNNNN NNNSNNSSNS SNNNNLPSSL RSIMNPMPQN DGTLDESDND
DDNNNNNNDN DNENNKDNID KLIIDGFKKN FNFNGDEVIP QNDGLNDDDD LDDEEIGGGG
GKVEEDSLGS DLDDDDDDDP DPIIEHFVLC QYEKVSRIKN KRKCNFKDGI MHLNGKDTLF
NKANGEMIWN
//
