ID TF_CAVPO Reviewed; 289 AA.
AC Q9JLU8;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-FEB-2023, entry version 103.
DE RecName: Full=Tissue factor;
DE Short=TF;
DE AltName: Full=Coagulation factor III;
DE AltName: CD_antigen=CD142;
DE Flags: Precursor;
GN Name=F3;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=10744153;
RA Shi R.J., Li W.Z., Marder V.J., Sporn L.A.;
RT "Cloning of guinea pig tissue factor cDNA: comparison of primary structure
RT among six mammalian species.";
RL Thromb. Haemost. 83:455-461(2000).
CC -!- FUNCTION: Initiates blood coagulation by forming a complex with
CC circulating factor VII or VIIa. The [TF:VIIa] complex activates factors
CC IX or X by specific limited proteolysis. TF plays a role in normal
CC hemostasis by initiating the cell-surface assembly and propagation of
CC the coagulation protease cascade.
CC -!- SUBUNIT: Interacts with HSPE; the interaction, inhibited by heparin,
CC promotes the generation of activated factor X and activates coagulation
CC in the presence of activated factor VII. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P13726}; Single-
CC pass type I membrane protein {ECO:0000250|UniProtKB:P13726}.
CC -!- SIMILARITY: Belongs to the tissue factor family. {ECO:0000305}.
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DR EMBL; AF131949; AAF36523.1; -; mRNA.
DR RefSeq; NP_001166375.1; NM_001172904.1.
DR AlphaFoldDB; Q9JLU8; -.
DR SMR; Q9JLU8; -.
DR STRING; 10141.ENSCPOP00000001894; -.
DR GlyCosmos; Q9JLU8; 4 sites, No reported glycans.
DR GeneID; 100135463; -.
DR KEGG; cpoc:100135463; -.
DR CTD; 2152; -.
DR eggNOG; ENOG502RA1F; Eukaryota.
DR InParanoid; Q9JLU8; -.
DR OrthoDB; 5321079at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR InterPro; IPR001187; Tissue_factor.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF22; TISSUE FACTOR; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR PIRSF; PIRSF002498; Tissue_factor_3; 1.
DR PRINTS; PR00346; TISSUEFACTOR.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 2: Evidence at transcript level;
KW Blood coagulation; Disulfide bond; Glycoprotein; Hemostasis; Lipoprotein;
KW Membrane; Palmitate; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000250"
FT CHAIN 33..289
FT /note="Tissue factor"
FT /id="PRO_0000033637"
FT TOPO_DOM 33..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 44..46
FT /note="WKS motif"
FT MOTIF 75..77
FT /note="WKS motif"
FT LIPID 271
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 79..87
FT /evidence="ECO:0000250"
FT DISULFID 213..236
FT /evidence="ECO:0000250"
SQ SEQUENCE 289 AA; 32457 MW; 7AB97F8F58199FB1 CRC64;
MTTPAWPRLP HPEIAVVPTL LLGWVLVQVA GAEGIPVKPY NLTWKSTNFK TILEWEPKPI
NNVYTVQIST ALEDWKSICF SITATECDLT SEMAPNVQQT YLARVISLLP NSTGFLEDAV
YSNSPEFTPY QETNLGQPKI ESFKLVGTKL NVTVRDTQTL ARSNGTFLSL RDIFGKNLQY
MLYYWRSSTT GKKTAMTNTN EFLIDVDKGQ DYCFFVQAVI PSRKDNKKSP ESITVCTRLE
KGKFREMSFI VVPVILVIIV VIALFLLVCK CRKAKARQSG KEGSPLNIA
//
