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Database: UniProt
Entry: THS3_VITVI
LinkDB: THS3_VITVI
Original site: THS3_VITVI 
ID   THS3_VITVI              Reviewed;         392 AA.
AC   P51071; F6HP27;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   18-SEP-2019, entry version 111.
DE   RecName: Full=Stilbene synthase 3;
DE            EC=2.3.1.95;
DE   AltName: Full=PSV368;
DE   AltName: Full=Resveratrol synthase 3;
DE   AltName: Full=Trihydroxystilbene synthase 3;
DE            Short=StSy 3;
GN   OrderedLocusNames=VIT_16s0100g01030;
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pinot noir / PN40024;
RX   PubMed=17721507; DOI=10.1038/nature06148;
RA   Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C.,
RA   Casagrande A., Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A.,
RA   Legeai F., Hugueney P., Dasilva C., Horner D., Mica E., Jublot D.,
RA   Poulain J., Bruyere C., Billault A., Segurens B., Gouyvenoux M.,
RA   Ugarte E., Cattonaro F., Anthouard V., Vico V., Del Fabbro C.,
RA   Alaux M., Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I.,
RA   Moroldo M., Scalabrin S., Canaguier A., Le Clainche I., Malacrida G.,
RA   Durand E., Pesole G., Laucou V., Chatelet P., Merdinoglu D.,
RA   Delledonne M., Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F.,
RA   Pe M.E., Valle G., Morgante M., Caboche M., Adam-Blondon A.-F.,
RA   Weissenbach J., Quetier F., Wincker P.;
RT   "The grapevine genome sequence suggests ancestral hexaploidization in
RT   major angiosperm phyla.";
RL   Nature 449:463-467(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-392.
RC   STRAIN=cv. Optima;
RX   PubMed=1898048; DOI=10.1016/0003-9861(91)90234-a;
RA   Melchior F., Kindl H.;
RT   "Coordinate- and elicitor-dependent expression of stilbene synthase
RT   and phenylalanine ammonia-lyase genes in Vitis cv. Optima.";
RL   Arch. Biochem. Biophys. 288:552-557(1991).
CC   -!- FUNCTION: Mediates resistance to pathogens which are sensitive to
CC       stilbenes. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA
CC         + trans-resveratrol; Xref=Rhea:RHEA:11936, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:45713, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384; EC=2.3.1.95;
CC   -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC       biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate:
CC       step 2/2.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By stress.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily.
CC       Chalcone/stilbene synthases family. {ECO:0000305}.
DR   EMBL; FN596000; CCB56433.1; -; Genomic_DNA.
DR   EMBL; S63227; -; NOT_ANNOTATED_CDS; mRNA.
DR   SMR; P51071; -.
DR   STRING; 29760.VIT_16s0100g01030.t01; -.
DR   EnsemblPlants; VIT_16s0100g01030.t01; VIT_16s0100g01030.t01; VIT_16s0100g01030.
DR   Gramene; VIT_16s0100g01030.t01; VIT_16s0100g01030.t01; VIT_16s0100g01030.
DR   eggNOG; ENOG410IEWP; Eukaryota.
DR   eggNOG; COG3424; LUCA.
DR   InParanoid; P51071; -.
DR   UniPathway; UPA00372; UER00548.
DR   Proteomes; UP000009183; Chromosome 16.
DR   ExpressionAtlas; P51071; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050350; F:trihydroxystilbene synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synth_C.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR001099; Chalcone/stilbene_synthase_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Complete proteome; Cytoplasm; Plant defense;
KW   Reference proteome; Stress response; Transferase.
FT   CHAIN         1    392       Stilbene synthase 3.
FT                                /FTId=PRO_0000216084.
FT   REGION       55     58       Substrate binding. {ECO:0000250}.
FT   REGION      305    307       Substrate binding. {ECO:0000250}.
FT   ACT_SITE    164    164       {ECO:0000255|PROSITE-ProRule:PRU10023}.
FT   BINDING     267    267       Substrate; via carbonyl oxygen.
FT                                {ECO:0000250}.
FT   CONFLICT     48     50       HMT -> PMS (in Ref. 1; S63227).
FT                                {ECO:0000305}.
FT   CONFLICT    100    100       V -> A (in Ref. 1; S63227).
FT                                {ECO:0000305}.
SQ   SEQUENCE   392 AA;  42816 MW;  F0455E63E51F69FA CRC64;
     MASVEEIRNA QRAKGPATIL AIGTATPDHC VYQSDYADYY FRVTKSEHMT ELKKKFNRIC
     DKSMIKKRYI HLTEEMLEEH PNIGAYMAPS LNIRQEIITV EVPKLGKEAA LKALKEWGQP
     KSKITHLVFC TTSGVEMPGA DYKLANLLGL ETSVRRVMLY HQGCYAGGTV LRTAKDLAEN
     NAGARVLVVC SEITVVTFRG PSEDALDSLV GQALFGDGSA AVIVGSDPDV SIERPLFQLV
     SAAQTFIPNS AGAIAGNLRE VGLTFHLWPN VPTLISENVE KCLTQAFDPL GISDWNSLFW
     IAHPGGPAIL DAVEAKLNLD KKKLEATRHV LSEYGNMSSA CVLFILDEMR KKSHKGEKAT
     TGEGLDWGVL FGFGPGLTIE TVVLHSIPMV TN
//
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