ID TIP22_ORYSJ Reviewed; 248 AA.
AC Q5Z6F0; B7EMA5; Q0DCF3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=Probable aquaporin TIP2-2;
DE AltName: Full=Tonoplast intrinsic protein 2-2;
DE Short=OsTIP2;2;
GN Name=TIP2-2; OrderedLocusNames=Os06g0336200, LOC_Os06g22960;
GN ORFNames=OsJ_020360, OSJNBa0012F14.45-1, P0427E01.5-1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16033806; DOI=10.1093/pcp/pci172;
RA Sakurai J., Ishikawa F., Yamaguchi T., Uemura M., Maeshima M.;
RT "Identification of 33 rice aquaporin genes and analysis of their expression
RT and function.";
RL Plant Cell Physiol. 46:1568-1577(2005).
CC -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC neutral solutes across cell membranes. May be involved in transport
CC from the vacuolar compartment to the cytoplasm (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Tonoplast.
CC -!- TISSUE SPECIFICITY: Expressed in roots and leaves.
CC {ECO:0000269|PubMed:16033806}.
CC -!- INDUCTION: Down-regulated by chilling. {ECO:0000269|PubMed:16033806}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC
CC 1.A.8.10) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF19470.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP004784; BAD61899.1; -; Genomic_DNA.
DR EMBL; AP005449; BAD61902.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF19470.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014962; BAS97594.1; -; Genomic_DNA.
DR EMBL; CM000143; EAZ36877.1; -; Genomic_DNA.
DR EMBL; AK073531; BAG93502.1; -; mRNA.
DR EMBL; AK099015; BAG93869.1; -; mRNA.
DR EMBL; AK099141; BAG93947.1; -; mRNA.
DR EMBL; AK099616; BAG94223.1; -; mRNA.
DR EMBL; AK104270; BAG96560.1; -; mRNA.
DR EMBL; AK104377; BAG96632.1; -; mRNA.
DR EMBL; AK104464; BAG96705.1; -; mRNA.
DR RefSeq; XP_015643913.1; XM_015788427.1.
DR AlphaFoldDB; Q5Z6F0; -.
DR SMR; Q5Z6F0; -.
DR STRING; 39947.Q5Z6F0; -.
DR PaxDb; 39947-Q5Z6F0; -.
DR EnsemblPlants; Os06t0336200-01; Os06t0336200-01; Os06g0336200.
DR GeneID; 4340941; -.
DR Gramene; Os06t0336200-01; Os06t0336200-01; Os06g0336200.
DR KEGG; osa:4340941; -.
DR eggNOG; KOG0223; Eukaryota.
DR HOGENOM; CLU_020019_3_4_1; -.
DR InParanoid; Q5Z6F0; -.
DR OMA; KMFWRAV; -.
DR OrthoDB; 3236018at2759; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR ExpressionAtlas; Q5Z6F0; baseline and differential.
DR Genevisible; Q5Z6F0; OS.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR45665; AQUAPORIN-8; 1.
DR PANTHER; PTHR45665:SF9; AQUAPORIN-8; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport; Vacuole.
FT CHAIN 1..248
FT /note="Probable aquaporin TIP2-2"
FT /id="PRO_0000064024"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT MOTIF 84..86
FT /note="NPA 1"
FT MOTIF 196..198
FT /note="NPA 2"
SQ SEQUENCE 248 AA; 25014 MW; B69F86CF3AEDCF25 CRC64;
MSGNIAFGRF DDSFSAASLK AYVAEFISTL VFVFAGVGSA IAYTKLTGGA PLDPAGLVAV
AVCHGFGLFV AVAIGANISG GHVNPAVTFG LALGGQITIL TGVFYWIAQL LGAIVGAVLV
QFCTGVATPT HGLSGVGAFE GVVMEIIVTF GLVYTVYATA ADPKKGSLGT IAPIAIGFIV
GANILVAGPF SGGSMNPARS FGPAVASGDY TNIWIYWVGP LVGGGLAGLV YRYVYMCGDH
APVASSEF
//
