ID   TIPIN_DANRE             Reviewed;         294 AA.
AC   Q6DBR4;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=TIMELESS-interacting protein;
GN   Name=tipin; ORFNames=zgc:91928;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the control of DNA replication and
CC       the maintenance of replication fork stability. Important for cell
CC       survival after DNA damage or replication stress. May be required for
CC       the replication checkpoint induced by hydroxyurea or ultraviolet light
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TIMELESS, which impairs TIMELESS self-
CC       association. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR   EMBL; BC078398; AAH78398.1; -; mRNA.
DR   RefSeq; NP_001003452.2; NM_001003452.2.
DR   AlphaFoldDB; Q6DBR4; -.
DR   SMR; Q6DBR4; -.
DR   STRING; 7955.ENSDARP00000052473; -.
DR   PaxDb; 7955-ENSDARP00000052473; -.
DR   GeneID; 445058; -.
DR   KEGG; dre:445058; -.
DR   AGR; ZFIN:ZDB-GENE-040801-189; -.
DR   CTD; 54962; -.
DR   ZFIN; ZDB-GENE-040801-189; tipin.
DR   eggNOG; KOG3004; Eukaryota.
DR   InParanoid; Q6DBR4; -.
DR   OMA; MNDQQDD; -.
DR   OrthoDB; 2920045at2759; -.
DR   PhylomeDB; Q6DBR4; -.
DR   PRO; PR:Q6DBR4; -.
DR   Proteomes; UP000000437; Alternate scaffold 7.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000110772; Expressed in superior colliculus and 10 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0044770; P:cell cycle phase transition; ISS:BHF-UCL.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR   GO; GO:0031297; P:replication fork processing; IEA:InterPro.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR   PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; DNA damage; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..294
FT                   /note="TIMELESS-interacting protein"
FT                   /id="PRO_0000305257"
FT   REGION          20..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..150
FT                   /note="Interaction with TIMELESS"
FT                   /evidence="ECO:0000250"
FT   REGION          168..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..263
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   294 AA;  33181 MW;  F2C4090C394DCC89 CRC64;
     MIDPLENGLF DIPDYEQIED ETFPPLPPPL SPGRAELEDD LFGNAEGEEE GEVSKLAEVP
     VAKRRTVKRP RPKLDANRLI SEKGLPALRT LFEDVKFKGK GHETENLKLL MLKMENWAHR
     LYPKMQFEEF IDKVENLGGK KEVQTCLKRI RLDMPITHED YVAEEAEIQV PEESVPSGDG
     GFPEDPFIHS TPAPASLTEE QQQRIELNKR LALERRLAKQ KQLESTPISI QEDADEPSTS
     SSGQFLSEEN PKTTSNQTPL KHKPAELQES PLHDNESSSH IANGIIDDDD DDDD
//