ID TM14A_PIG Reviewed; 99 AA.
AC P56984;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 24-JAN-2024, entry version 97.
DE RecName: Full=Transmembrane protein 14A;
GN Name=TMEM14A;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fahrenkrug S.C., Freking B.A., Rohrer G.A., Smith T.P.L., Casas E.,
RA Stone R.T., Heaton M.P., Grosse W.M., Bennett G.A., Laegreid W.W.,
RA Keele J.W.;
RT "Design and use of two pooled tissue normalized cDNA libraries for EST
RT discovery in swine.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP RECONSTRUCTION FROM ESTS.
RA Bairoch A.;
RL Unpublished observations (AUG-2000).
CC -!- FUNCTION: Inhibits apoptosis via negative regulation of the
CC mitochondrial outer membrane permeabilization involved in apoptotic
CC signaling pathway. {ECO:0000250|UniProtKB:Q9Y6G1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q9Y6G1}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9Y6G1}.
CC -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR EMBL; BE233236; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_003128844.1; XM_003128796.3.
DR RefSeq; XP_003482377.1; XM_003482329.3.
DR RefSeq; XP_005666526.1; XM_005666469.2.
DR RefSeq; XP_013833906.1; XM_013978452.1.
DR AlphaFoldDB; P56984; -.
DR SMR; P56984; -.
DR STRING; 9823.ENSSSCP00000002830; -.
DR PaxDb; 9823-ENSSSCP00000002830; -.
DR Ensembl; ENSSSCT00000002909.4; ENSSSCP00000002830.2; ENSSSCG00000002622.4.
DR Ensembl; ENSSSCT00005029139.1; ENSSSCP00005017790.1; ENSSSCG00005018506.1.
DR Ensembl; ENSSSCT00005029151.1; ENSSSCP00005017799.1; ENSSSCG00005018506.1.
DR Ensembl; ENSSSCT00015073756.1; ENSSSCP00015029616.1; ENSSSCG00015055381.1.
DR Ensembl; ENSSSCT00025067316.1; ENSSSCP00025028809.1; ENSSSCG00025049444.1.
DR Ensembl; ENSSSCT00030068883.1; ENSSSCP00030031462.1; ENSSSCG00030049402.1.
DR Ensembl; ENSSSCT00035088107.1; ENSSSCP00035036806.1; ENSSSCG00035065416.1.
DR Ensembl; ENSSSCT00040007054.1; ENSSSCP00040002798.1; ENSSSCG00040005339.1.
DR Ensembl; ENSSSCT00045005175.1; ENSSSCP00045003430.1; ENSSSCG00045003203.1.
DR Ensembl; ENSSSCT00050001590.1; ENSSSCP00050000446.1; ENSSSCG00050001339.1.
DR Ensembl; ENSSSCT00055026043.1; ENSSSCP00055020696.1; ENSSSCG00055013247.1.
DR Ensembl; ENSSSCT00060012938.1; ENSSSCP00060004894.1; ENSSSCG00060010005.1.
DR Ensembl; ENSSSCT00065045455.1; ENSSSCP00065019489.1; ENSSSCG00065033455.1.
DR Ensembl; ENSSSCT00070017587.1; ENSSSCP00070014579.1; ENSSSCG00070009067.1.
DR Ensembl; ENSSSCT00070017596.1; ENSSSCP00070014587.1; ENSSSCG00070009067.1.
DR Ensembl; ENSSSCT00070017603.1; ENSSSCP00070014592.1; ENSSSCG00070009067.1.
DR GeneID; 100512176; -.
DR KEGG; ssc:100512176; -.
DR CTD; 28978; -.
DR VGNC; VGNC:94094; TMEM14A.
DR eggNOG; KOG4267; Eukaryota.
DR GeneTree; ENSGT00940000158206; -.
DR HOGENOM; CLU_096652_4_3_1; -.
DR InParanoid; P56984; -.
DR OMA; MGTRYKK; -.
DR OrthoDB; 5348983at2759; -.
DR TreeFam; TF323345; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Proteomes; UP000314985; Chromosome 7.
DR Proteomes; UP000694570; Unplaced.
DR Proteomes; UP000694571; Unplaced.
DR Proteomes; UP000694720; Unplaced.
DR Proteomes; UP000694722; Unplaced.
DR Proteomes; UP000694723; Unplaced.
DR Proteomes; UP000694724; Unplaced.
DR Proteomes; UP000694725; Unplaced.
DR Proteomes; UP000694726; Unplaced.
DR Proteomes; UP000694727; Unplaced.
DR Proteomes; UP000694728; Unplaced.
DR Bgee; ENSSSCG00000002622; Expressed in epididymis and 45 other cell types or tissues.
DR ExpressionAtlas; P56984; baseline and differential.
DR Genevisible; P56984; SS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR Gene3D; 6.10.250.1330; -; 1.
DR Gene3D; 1.10.10.1740; Transmembrane protein 14-like; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; TRANSMEMBRANE PROTEIN 14, 15; 1.
DR PANTHER; PTHR12668:SF11; TRANSMEMBRANE PROTEIN 14A; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..99
FT /note="Transmembrane protein 14A"
FT /id="PRO_0000221171"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 10717 MW; D416ADAED9F34AE4 CRC64;
MDLIGFGYAA LVTFGSILGY KRRGGVPSLI AGLFVGFLAG YGAYRVSLDK RDVKLSLFTA
FFLATIMGVR FKRSKKIMPA GLVAGLSLLM ILRLVLLLL
//
