ID TM14B_HUMAN Reviewed; 114 AA.
AC Q9NUH8; Q5THN7; Q5THN8; Q96IX7; Q9BVN8;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 161.
DE RecName: Full=Transmembrane protein 14B;
GN Name=TMEM14B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Liver, Placenta, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, INTERACTION WITH IQGAP1, AND TISSUE SPECIFICITY.
RX PubMed=29033352; DOI=10.1016/j.stem.2017.08.013;
RA Liu J., Liu W., Yang L., Wu Q., Zhang H., Fang A., Li L., Xu X., Sun L.,
RA Zhang J., Tang F., Wang X.;
RT "The primate-specific gene TMEM14B marks outer radial glia cells and
RT promotes cortical expansion and folding.";
RL Cell Stem Cell 21:635-649(2017).
CC -!- FUNCTION: Primate-specific protein involved in cortical expansion and
CC folding in the developing neocortex. May drive neural progenitor
CC proliferation through nuclear translocation of IQGAP1, which in turn
CC promotes G1/S cell cycle transitions. {ECO:0000269|PubMed:29033352}.
CC -!- SUBUNIT: Interacts with IQGAP1; this interaction promotes
CC phosphorylation and nuclear translocation of IQGAP1.
CC {ECO:0000269|PubMed:29033352}.
CC -!- INTERACTION:
CC Q9NUH8; O95870: ABHD16A; NbExp=3; IntAct=EBI-8638294, EBI-348517;
CC Q9NUH8; Q8WTS1: ABHD5; NbExp=3; IntAct=EBI-8638294, EBI-2813554;
CC Q9NUH8; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-8638294, EBI-2876927;
CC Q9NUH8; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-8638294, EBI-10225815;
CC Q9NUH8; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-8638294, EBI-2803601;
CC Q9NUH8; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-8638294, EBI-1754287;
CC Q9NUH8; Q8TD06: AGR3; NbExp=3; IntAct=EBI-8638294, EBI-3925742;
CC Q9NUH8; P55056: APOC4; NbExp=3; IntAct=EBI-8638294, EBI-18302142;
CC Q9NUH8; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-8638294, EBI-714543;
CC Q9NUH8; Q9NVJ2: ARL8B; NbExp=3; IntAct=EBI-8638294, EBI-718376;
CC Q9NUH8; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-8638294, EBI-11724186;
CC Q9NUH8; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-8638294, EBI-12069500;
CC Q9NUH8; Q9UBV7: B4GALT7; NbExp=3; IntAct=EBI-8638294, EBI-10319970;
CC Q9NUH8; Q13323: BIK; NbExp=3; IntAct=EBI-8638294, EBI-700794;
CC Q9NUH8; P62952: BLCAP; NbExp=3; IntAct=EBI-8638294, EBI-3895726;
CC Q9NUH8; O95393: BMP10; NbExp=3; IntAct=EBI-8638294, EBI-3922513;
CC Q9NUH8; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-8638294, EBI-8648738;
CC Q9NUH8; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-8638294, EBI-13381098;
CC Q9NUH8; O14523: C2CD2L; NbExp=3; IntAct=EBI-8638294, EBI-12822627;
CC Q9NUH8; P13236: CCL4; NbExp=3; IntAct=EBI-8638294, EBI-2873970;
CC Q9NUH8; P11912: CD79A; NbExp=3; IntAct=EBI-8638294, EBI-7797864;
CC Q9NUH8; Q9Y6K0: CEPT1; NbExp=3; IntAct=EBI-8638294, EBI-1237183;
CC Q9NUH8; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-8638294, EBI-11579371;
CC Q9NUH8; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-8638294, EBI-7062247;
CC Q9NUH8; P78369: CLDN10; NbExp=3; IntAct=EBI-8638294, EBI-13372810;
CC Q9NUH8; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-8638294, EBI-11959453;
CC Q9NUH8; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-8638294, EBI-11522780;
CC Q9NUH8; Q8IZV2: CMTM8; NbExp=3; IntAct=EBI-8638294, EBI-7868911;
CC Q9NUH8; Q6PI25: CNIH2; NbExp=3; IntAct=EBI-8638294, EBI-12815321;
CC Q9NUH8; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-8638294, EBI-12208021;
CC Q9NUH8; Q9P003: CNIH4; NbExp=3; IntAct=EBI-8638294, EBI-1044341;
CC Q9NUH8; P21964: COMT; NbExp=3; IntAct=EBI-8638294, EBI-372265;
CC Q9NUH8; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-8638294, EBI-18013275;
CC Q9NUH8; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8638294, EBI-6942903;
CC Q9NUH8; P49447: CYB561; NbExp=3; IntAct=EBI-8638294, EBI-8646596;
CC Q9NUH8; P00387: CYB5R3; NbExp=3; IntAct=EBI-8638294, EBI-1046040;
CC Q9NUH8; P81534: DEFB103B; NbExp=3; IntAct=EBI-8638294, EBI-12074168;
CC Q9NUH8; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-8638294, EBI-12831978;
CC Q9NUH8; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-8638294, EBI-3923585;
CC Q9NUH8; Q15125: EBP; NbExp=3; IntAct=EBI-8638294, EBI-3915253;
CC Q9NUH8; O14681: EI24; NbExp=3; IntAct=EBI-8638294, EBI-2339413;
CC Q9NUH8; Q9BV81: EMC6; NbExp=3; IntAct=EBI-8638294, EBI-2820492;
CC Q9NUH8; Q8IUS5: EPHX4; NbExp=3; IntAct=EBI-8638294, EBI-17962164;
CC Q9NUH8; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-8638294, EBI-781551;
CC Q9NUH8; Q92935: EXTL1; NbExp=3; IntAct=EBI-8638294, EBI-1760167;
CC Q9NUH8; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-8638294, EBI-11337888;
CC Q9NUH8; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-8638294, EBI-3943864;
CC Q9NUH8; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8638294, EBI-18304435;
CC Q9NUH8; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-8638294, EBI-3385283;
CC Q9NUH8; Q14318: FKBP8; NbExp=3; IntAct=EBI-8638294, EBI-724839;
CC Q9NUH8; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-8638294, EBI-11110431;
CC Q9NUH8; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-8638294, EBI-11991950;
CC Q9NUH8; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-8638294, EBI-13345167;
CC Q9NUH8; Q8TED1: GPX8; NbExp=3; IntAct=EBI-8638294, EBI-11721746;
CC Q9NUH8; P02724: GYPA; NbExp=3; IntAct=EBI-8638294, EBI-702665;
CC Q9NUH8; P04921: GYPC; NbExp=3; IntAct=EBI-8638294, EBI-7797098;
CC Q9NUH8; P07686: HEXB; NbExp=3; IntAct=EBI-8638294, EBI-7133736;
CC Q9NUH8; P31937: HIBADH; NbExp=3; IntAct=EBI-8638294, EBI-11427100;
CC Q9NUH8; A8MV81: HIGD1C; NbExp=3; IntAct=EBI-8638294, EBI-12809676;
CC Q9NUH8; P09601: HMOX1; NbExp=3; IntAct=EBI-8638294, EBI-2806151;
CC Q9NUH8; P30519: HMOX2; NbExp=3; IntAct=EBI-8638294, EBI-712096;
CC Q9NUH8; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-8638294, EBI-1052304;
CC Q9NUH8; P14060: HSD3B1; NbExp=3; IntAct=EBI-8638294, EBI-17426018;
CC Q9NUH8; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-8638294, EBI-725665;
CC Q9NUH8; Q01628: IFITM3; NbExp=3; IntAct=EBI-8638294, EBI-7932862;
CC Q9NUH8; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-8638294, EBI-8503746;
CC Q9NUH8; P11215: ITGAM; NbExp=3; IntAct=EBI-8638294, EBI-2568251;
CC Q9NUH8; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-8638294, EBI-10266796;
CC Q9NUH8; Q09470: KCNA1; NbExp=3; IntAct=EBI-8638294, EBI-8286599;
CC Q9NUH8; O00180: KCNK1; NbExp=3; IntAct=EBI-8638294, EBI-3914675;
CC Q9NUH8; O95214: LEPROTL1; NbExp=3; IntAct=EBI-8638294, EBI-750776;
CC Q9NUH8; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-8638294, EBI-12033434;
CC Q9NUH8; Q9Y2L9-3: LRCH1; NbExp=3; IntAct=EBI-8638294, EBI-12082218;
CC Q9NUH8; Q969L2: MAL2; NbExp=3; IntAct=EBI-8638294, EBI-944295;
CC Q9NUH8; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-8638294, EBI-2341610;
CC Q9NUH8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-8638294, EBI-16439278;
CC Q9NUH8; Q6NUT3-2: MFSD12; NbExp=3; IntAct=EBI-8638294, EBI-17295698;
CC Q9NUH8; Q6N075: MFSD5; NbExp=3; IntAct=EBI-8638294, EBI-3920969;
CC Q9NUH8; O43451: MGAM; NbExp=3; IntAct=EBI-8638294, EBI-2829774;
CC Q9NUH8; Q8IY49-2: MMD2; NbExp=3; IntAct=EBI-8638294, EBI-13349813;
CC Q9NUH8; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-8638294, EBI-12070086;
CC Q9NUH8; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-8638294, EBI-12820341;
CC Q9NUH8; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-8638294, EBI-2863634;
CC Q9NUH8; O95167: NDUFA3; NbExp=3; IntAct=EBI-8638294, EBI-1246131;
CC Q9NUH8; Q99519: NEU1; NbExp=3; IntAct=EBI-8638294, EBI-721517;
CC Q9NUH8; Q92982: NINJ1; NbExp=3; IntAct=EBI-8638294, EBI-2802124;
CC Q9NUH8; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-8638294, EBI-10317425;
CC Q9NUH8; Q6P499: NIPAL3; NbExp=3; IntAct=EBI-8638294, EBI-10252783;
CC Q9NUH8; Q8N912: NRAC; NbExp=3; IntAct=EBI-8638294, EBI-12051377;
CC Q9NUH8; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-8638294, EBI-1054848;
CC Q9NUH8; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-8638294, EBI-6916492;
CC Q9NUH8; O75459: PAGE1; NbExp=3; IntAct=EBI-8638294, EBI-2559100;
CC Q9NUH8; Q86YL7: PDPN; NbExp=3; IntAct=EBI-8638294, EBI-723160;
CC Q9NUH8; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-8638294, EBI-716063;
CC Q9NUH8; Q96HA9: PEX11G; NbExp=3; IntAct=EBI-8638294, EBI-17284886;
CC Q9NUH8; Q07326: PIGF; NbExp=3; IntAct=EBI-8638294, EBI-17180304;
CC Q9NUH8; Q9Y342: PLLP; NbExp=3; IntAct=EBI-8638294, EBI-3919291;
CC Q9NUH8; P60201-2: PLP1; NbExp=3; IntAct=EBI-8638294, EBI-12188331;
CC Q9NUH8; Q04941: PLP2; NbExp=3; IntAct=EBI-8638294, EBI-608347;
CC Q9NUH8; Q01453: PMP22; NbExp=3; IntAct=EBI-8638294, EBI-2845982;
CC Q9NUH8; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-8638294, EBI-8652812;
CC Q9NUH8; O60831: PRAF2; NbExp=3; IntAct=EBI-8638294, EBI-2506064;
CC Q9NUH8; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-8638294, EBI-7199479;
CC Q9NUH8; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-8638294, EBI-712367;
CC Q9NUH8; Q02161-2: RHD; NbExp=3; IntAct=EBI-8638294, EBI-17249212;
CC Q9NUH8; Q8IXI1: RHOT2; NbExp=3; IntAct=EBI-8638294, EBI-1396563;
CC Q9NUH8; Q9Y6B6: SAR1B; NbExp=3; IntAct=EBI-8638294, EBI-4290665;
CC Q9NUH8; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-8638294, EBI-2695784;
CC Q9NUH8; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8638294, EBI-17247926;
CC Q9NUH8; O75711: SCRG1; NbExp=3; IntAct=EBI-8638294, EBI-10189029;
CC Q9NUH8; O75920: SERF1B; NbExp=3; IntAct=EBI-8638294, EBI-2115181;
CC Q9NUH8; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-8638294, EBI-10329948;
CC Q9NUH8; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-8638294, EBI-749270;
CC Q9NUH8; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-8638294, EBI-2854842;
CC Q9NUH8; O95562: SFT2D2; NbExp=3; IntAct=EBI-8638294, EBI-4402330;
CC Q9NUH8; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-8638294, EBI-355861;
CC Q9NUH8; Q96NB2: SFXN2; NbExp=3; IntAct=EBI-8638294, EBI-6381136;
CC Q9NUH8; Q9BWM7: SFXN3; NbExp=3; IntAct=EBI-8638294, EBI-1171999;
CC Q9NUH8; Q8TF71: SLC16A10; NbExp=3; IntAct=EBI-8638294, EBI-17858931;
CC Q9NUH8; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-8638294, EBI-12243266;
CC Q9NUH8; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-8638294, EBI-17595455;
CC Q9NUH8; Q9BZV2: SLC19A3; NbExp=3; IntAct=EBI-8638294, EBI-3923779;
CC Q9NUH8; Q9UGQ3: SLC2A6; NbExp=3; IntAct=EBI-8638294, EBI-18004831;
CC Q9NUH8; Q99726: SLC30A3; NbExp=3; IntAct=EBI-8638294, EBI-10294651;
CC Q9NUH8; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-8638294, EBI-10262251;
CC Q9NUH8; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-8638294, EBI-12363689;
CC Q9NUH8; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8638294, EBI-17295964;
CC Q9NUH8; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-8638294, EBI-13389236;
CC Q9NUH8; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-8638294, EBI-12867720;
CC Q9NUH8; Q5T1Q4: SLC35F1; NbExp=3; IntAct=EBI-8638294, EBI-13365456;
CC Q9NUH8; Q8N357: SLC35F6; NbExp=3; IntAct=EBI-8638294, EBI-713484;
CC Q9NUH8; Q2M3R5: SLC35G1; NbExp=3; IntAct=EBI-8638294, EBI-13311257;
CC Q9NUH8; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-8638294, EBI-12898013;
CC Q9NUH8; Q92504: SLC39A7; NbExp=3; IntAct=EBI-8638294, EBI-1051105;
CC Q9NUH8; Q6P1K1: SLC48A1; NbExp=3; IntAct=EBI-8638294, EBI-1222191;
CC Q9NUH8; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-8638294, EBI-13292283;
CC Q9NUH8; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-8638294, EBI-10226799;
CC Q9NUH8; O60906: SMPD2; NbExp=3; IntAct=EBI-8638294, EBI-12828299;
CC Q9NUH8; Q14534: SQLE; NbExp=3; IntAct=EBI-8638294, EBI-3905171;
CC Q9NUH8; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-8638294, EBI-12908338;
CC Q9NUH8; P27105: STOM; NbExp=3; IntAct=EBI-8638294, EBI-1211440;
CC Q9NUH8; Q86Y82: STX12; NbExp=3; IntAct=EBI-8638294, EBI-2691717;
CC Q9NUH8; Q13277: STX3; NbExp=3; IntAct=EBI-8638294, EBI-1394295;
CC Q9NUH8; O43752: STX6; NbExp=3; IntAct=EBI-8638294, EBI-2695795;
CC Q9NUH8; Q9UNK0: STX8; NbExp=3; IntAct=EBI-8638294, EBI-727240;
CC Q9NUH8; Q9BXA5: SUCNR1; NbExp=3; IntAct=EBI-8638294, EBI-17962797;
CC Q9NUH8; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-8638294, EBI-12187159;
CC Q9NUH8; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-8638294, EBI-1049004;
CC Q9NUH8; Q03518: TAP1; NbExp=3; IntAct=EBI-8638294, EBI-747259;
CC Q9NUH8; P59542: TAS2R19; NbExp=3; IntAct=EBI-8638294, EBI-12847034;
CC Q9NUH8; Q96BZ9: TBC1D20; NbExp=3; IntAct=EBI-8638294, EBI-9254454;
CC Q9NUH8; Q53QW1: TEX44; NbExp=3; IntAct=EBI-8638294, EBI-10278496;
CC Q9NUH8; P07204: THBD; NbExp=3; IntAct=EBI-8638294, EBI-941422;
CC Q9NUH8; Q9Y584: TIMM22; NbExp=3; IntAct=EBI-8638294, EBI-1200494;
CC Q9NUH8; O14925: TIMM23; NbExp=3; IntAct=EBI-8638294, EBI-1047996;
CC Q9NUH8; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-8638294, EBI-6268651;
CC Q9NUH8; Q96CP7: TLCD1; NbExp=3; IntAct=EBI-8638294, EBI-11337932;
CC Q9NUH8; P48230: TM4SF4; NbExp=3; IntAct=EBI-8638294, EBI-8650934;
CC Q9NUH8; P17152: TMEM11; NbExp=3; IntAct=EBI-8638294, EBI-723946;
CC Q9NUH8; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-8638294, EBI-727322;
CC Q9NUH8; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-8638294, EBI-10171534;
CC Q9NUH8; Q9BTD3: TMEM121; NbExp=3; IntAct=EBI-8638294, EBI-12155101;
CC Q9NUH8; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-8638294, EBI-348587;
CC Q9NUH8; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-8638294, EBI-2800360;
CC Q9NUH8; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-8638294, EBI-8638294;
CC Q9NUH8; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-8638294, EBI-2339195;
CC Q9NUH8; Q14656: TMEM187; NbExp=3; IntAct=EBI-8638294, EBI-13046724;
CC Q9NUH8; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-8638294, EBI-741829;
CC Q9NUH8; Q8N511: TMEM199; NbExp=3; IntAct=EBI-8638294, EBI-10265825;
CC Q9NUH8; Q969S6: TMEM203; NbExp=3; IntAct=EBI-8638294, EBI-12274070;
CC Q9NUH8; Q6QAJ8: TMEM220; NbExp=3; IntAct=EBI-8638294, EBI-17963211;
CC Q9NUH8; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-8638294, EBI-347385;
CC Q9NUH8; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-8638294, EBI-12195227;
CC Q9NUH8; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-8638294, EBI-12887458;
CC Q9NUH8; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-8638294, EBI-11956809;
CC Q9NUH8; Q8WV15: TMEM255B; NbExp=3; IntAct=EBI-8638294, EBI-2870087;
CC Q9NUH8; Q0VDI3: TMEM267; NbExp=3; IntAct=EBI-8638294, EBI-17555467;
CC Q9NUH8; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-8638294, EBI-12038591;
CC Q9NUH8; O95807: TMEM50A; NbExp=3; IntAct=EBI-8638294, EBI-12903814;
CC Q9NUH8; P56557: TMEM50B; NbExp=3; IntAct=EBI-8638294, EBI-12366453;
CC Q9NUH8; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-8638294, EBI-726044;
CC Q9NUH8; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-8638294, EBI-2852148;
CC Q9NUH8; Q5SWH9: TMEM69; NbExp=3; IntAct=EBI-8638294, EBI-17963363;
CC Q9NUH8; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-8638294, EBI-12111910;
CC Q9NUH8; Q9BVT8: TMUB1; NbExp=3; IntAct=EBI-8638294, EBI-11425701;
CC Q9NUH8; Q9Y320: TMX2; NbExp=3; IntAct=EBI-8638294, EBI-6447886;
CC Q9NUH8; Q96B49: TOMM6; NbExp=3; IntAct=EBI-8638294, EBI-10826510;
CC Q9NUH8; O60636: TSPAN2; NbExp=3; IntAct=EBI-8638294, EBI-3914288;
CC Q9NUH8; P30536: TSPO; NbExp=3; IntAct=EBI-8638294, EBI-6623146;
CC Q9NUH8; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-8638294, EBI-11343401;
CC Q9NUH8; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-8638294, EBI-988826;
CC Q9NUH8; Q8N2K1: UBE2J2; NbExp=3; IntAct=EBI-8638294, EBI-2340110;
CC Q9NUH8; Q05086-3: UBE3A; NbExp=3; IntAct=EBI-8638294, EBI-11026619;
CC Q9NUH8; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-8638294, EBI-2819725;
CC Q9NUH8; O00124: UBXN8; NbExp=3; IntAct=EBI-8638294, EBI-1993850;
CC Q9NUH8; Q53HI1: UNC50; NbExp=3; IntAct=EBI-8638294, EBI-7601760;
CC Q9NUH8; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-8638294, EBI-13356252;
CC Q9NUH8; P23763-3: VAMP1; NbExp=3; IntAct=EBI-8638294, EBI-12097582;
CC Q9NUH8; O95183: VAMP5; NbExp=3; IntAct=EBI-8638294, EBI-10191195;
CC Q9NUH8; Q86Y07: VRK2; NbExp=3; IntAct=EBI-8638294, EBI-1207615;
CC Q9NUH8; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-8638294, EBI-723716;
CC Q9NUH8; O95070: YIF1A; NbExp=3; IntAct=EBI-8638294, EBI-2799703;
CC Q9NUH8; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-8638294, EBI-7850136;
CC Q9NUH8; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-8638294, EBI-751204;
CC Q9NUH8; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-8638294, EBI-751253;
CC Q9NUH8; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-8638294, EBI-751210;
CC Q9NUH8; Q9H8X9: ZDHHC11; NbExp=3; IntAct=EBI-8638294, EBI-17961574;
CC Q9NUH8; Q8N966: ZDHHC22; NbExp=3; IntAct=EBI-8638294, EBI-10268111;
CC Q9NUH8; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-8638294, EBI-10254561;
CC Q9NUH8; O95159: ZFPL1; NbExp=3; IntAct=EBI-8638294, EBI-718439;
CC Q9NUH8; A0A087WZY1; NbExp=3; IntAct=EBI-8638294, EBI-13387614;
CC Q9NUH8; P0DTD8: 7b; Xeno; NbExp=3; IntAct=EBI-8638294, EBI-25475914;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NUH8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NUH8-2; Sequence=VSP_046899;
CC -!- TISSUE SPECIFICITY: Mainly expressed in the outer subventricular zone
CC (OSVZ) of the fetal brains. {ECO:0000269|PubMed:29033352}.
CC -!- MISCELLANEOUS: When expressed in embryonic mouse neocortex, induces
CC intermediate progenitor cells and outer radial glia expansion, cortical
CC thickening and induces gyrification (PubMed:29033352).
CC {ECO:0000269|PubMed:29033352}.
CC -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR EMBL; AL024498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55279.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55281.1; -; Genomic_DNA.
DR EMBL; BC001033; AAH01033.1; -; mRNA.
DR EMBL; BC007080; AAH07080.1; -; mRNA.
DR EMBL; BC013913; AAH13913.1; -; mRNA.
DR EMBL; BC071660; AAH71660.1; -; mRNA.
DR CCDS; CCDS4515.1; -. [Q9NUH8-1]
DR CCDS; CCDS47372.1; -. [Q9NUH8-2]
DR RefSeq; NP_001121183.1; NM_001127711.2. [Q9NUH8-2]
DR RefSeq; NP_001273413.1; NM_001286484.1.
DR RefSeq; NP_112231.3; NM_030969.4. [Q9NUH8-1]
DR AlphaFoldDB; Q9NUH8; -.
DR BioGRID; 123603; 274.
DR IntAct; Q9NUH8; 217.
DR MINT; Q9NUH8; -.
DR STRING; 9606.ENSP00000420658; -.
DR TCDB; 2.A.126.1.20; the fatty acid exporter (fax) family.
DR iPTMnet; Q9NUH8; -.
DR PhosphoSitePlus; Q9NUH8; -.
DR BioMuta; TMEM14B; -.
DR DMDM; 27734593; -.
DR MassIVE; Q9NUH8; -.
DR MaxQB; Q9NUH8; -.
DR PaxDb; 9606-ENSP00000420658; -.
DR PeptideAtlas; Q9NUH8; -.
DR Pumba; Q9NUH8; -.
DR TopDownProteomics; Q9NUH8-1; -. [Q9NUH8-1]
DR Antibodypedia; 52852; 33 antibodies from 7 providers.
DR DNASU; 81853; -.
DR Ensembl; ENST00000379530.7; ENSP00000368845.3; ENSG00000137210.14. [Q9NUH8-2]
DR Ensembl; ENST00000379542.10; ENSP00000368858.5; ENSG00000137210.14. [Q9NUH8-1]
DR GeneID; 81853; -.
DR KEGG; hsa:81853; -.
DR MANE-Select; ENST00000379542.10; ENSP00000368858.5; NM_030969.5; NP_112231.3.
DR UCSC; uc003mzk.5; human. [Q9NUH8-1]
DR AGR; HGNC:21384; -.
DR CTD; 81853; -.
DR DisGeNET; 81853; -.
DR GeneCards; TMEM14B; -.
DR HGNC; HGNC:21384; TMEM14B.
DR HPA; ENSG00000137210; Low tissue specificity.
DR MIM; 619865; gene.
DR neXtProt; NX_Q9NUH8; -.
DR OpenTargets; ENSG00000137210; -.
DR PharmGKB; PA134964501; -.
DR VEuPathDB; HostDB:ENSG00000137210; -.
DR GeneTree; ENSGT00940000163914; -.
DR HOGENOM; CLU_096652_4_0_1; -.
DR InParanoid; Q9NUH8; -.
DR OrthoDB; 4658722at2759; -.
DR TreeFam; TF323345; -.
DR PathwayCommons; Q9NUH8; -.
DR SignaLink; Q9NUH8; -.
DR BioGRID-ORCS; 81853; 23 hits in 1144 CRISPR screens.
DR ChiTaRS; TMEM14B; human.
DR GenomeRNAi; 81853; -.
DR Pharos; Q9NUH8; Tbio.
DR PRO; PR:Q9NUH8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9NUH8; Protein.
DR Bgee; ENSG00000137210; Expressed in oocyte and 193 other cell types or tissues.
DR ExpressionAtlas; Q9NUH8; baseline and differential.
DR Genevisible; Q9NUH8; HS.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0021987; P:cerebral cortex development; IMP:UniProtKB.
DR GO; GO:0061351; P:neural precursor cell proliferation; IDA:UniProtKB.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR Gene3D; 1.10.10.1740; Transmembrane protein 14-like; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; TRANSMEMBRANE PROTEIN 14, 15; 1.
DR PANTHER; PTHR12668:SF34; TRANSMEMBRANE PROTEIN 14B-RELATED; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Membrane; Neurogenesis;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..114
FT /note="Transmembrane protein 14B"
FT /id="PRO_0000221172"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 34..67
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046899"
FT CONFLICT 37
FT /note="P -> S (in Ref. 3; AAH07080)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="G -> W (in Ref. 3; AAH01033)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="Y -> C (in Ref. 3; AAH07080)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 114 AA; 12078 MW; AA2251A59C53BCB7 CRC64;
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG LGAYQLYQDP
RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL MAAKVGVRML MTSD
//
