ID TMED5_RAT Reviewed; 229 AA.
AC Q6AXN3;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE RecName: Full=Transmembrane emp24 domain-containing protein 5;
DE AltName: Full=p24 family protein gamma-2;
DE Short=p24gamma2;
DE Flags: Precursor;
GN Name=Tmed5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC the early secretory pathway. Required for the maintenance of the Golgi
CC apparatus; involved in protein exchange between Golgi stacks during
CC assembly. Probably not required for COPI-vesicle-mediated retrograde
CC transport (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TMED9 and TMED10. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus,
CC cis-Golgi network membrane {ECO:0000250}; Single-pass type I membrane
CC protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000250}; Single-pass type I membrane protein
CC {ECO:0000250}. Note=Probably cycles between compartments of the early
CC secretatory pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; BC079452; AAH79452.1; -; mRNA.
DR RefSeq; NP_001007620.1; NM_001007619.1.
DR AlphaFoldDB; Q6AXN3; -.
DR SMR; Q6AXN3; -.
DR STRING; 10116.ENSRNOP00000000083; -.
DR PhosphoSitePlus; Q6AXN3; -.
DR jPOST; Q6AXN3; -.
DR PaxDb; 10116-ENSRNOP00000000083; -.
DR Ensembl; ENSRNOT00000119350.1; ENSRNOP00000084338.1; ENSRNOG00000000073.7.
DR GeneID; 289883; -.
DR KEGG; rno:289883; -.
DR UCSC; RGD:1359437; rat.
DR AGR; RGD:1359437; -.
DR CTD; 50999; -.
DR RGD; 1359437; Tmed5.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00940000155468; -.
DR HOGENOM; CLU_066963_0_0_1; -.
DR InParanoid; Q6AXN3; -.
DR OrthoDB; 601480at2759; -.
DR Reactome; R-RNO-3238698; WNT ligand biogenesis and trafficking.
DR PRO; PR:Q6AXN3; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Genevisible; Q6AXN3; RN.
DR GO; GO:0005801; C:cis-Golgi network; ISS:UniProtKB.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0090161; P:Golgi ribbon formation; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF41; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..229
FT /note="Transmembrane emp24 domain-containing protein 5"
FT /id="PRO_0000010392"
FT TOPO_DOM 28..196
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 45..126
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ SEQUENCE 229 AA; 26136 MW; 2A2D8070B26F6C68 CRC64;
MGVRMWLPFP MLLLSALPAT LLSGAAGFTP SLDSDFTFTL PAGQKECFYQ PMPLKASLEI
EYQVLDGGEL DIDFHLASPE GRTLVFEQRK SDGVHTVETE DGDYMFCFDN TFSTISEKVI
FFELILDNMG EEVEGQEDWK KYITNTDVLE MKLEDILESI NSIKSRLSKS GHIQTLLRAF
EARDRNIQES NFDRVNFWSV VNLMVMVVVS AIQVYTLKSL FEDKRKSRT
//
