ID TMED6_BOVIN Reviewed; 240 AA.
AC Q0VCA9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=Transmembrane emp24 domain-containing protein 6;
DE AltName: Full=p24 family protein gamma-5;
DE Short=p24gamma5;
DE Flags: Precursor;
GN Name=TMED6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
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DR EMBL; BC120264; AAI20265.1; -; mRNA.
DR RefSeq; NP_001069456.1; NM_001075988.2.
DR AlphaFoldDB; Q0VCA9; -.
DR SMR; Q0VCA9; -.
DR STRING; 9913.ENSBTAP00000010015; -.
DR GlyCosmos; Q0VCA9; 2 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000010015; -.
DR Ensembl; ENSBTAT00000010015.5; ENSBTAP00000010015.4; ENSBTAG00000007616.5.
DR GeneID; 533277; -.
DR KEGG; bta:533277; -.
DR CTD; 146456; -.
DR VEuPathDB; HostDB:ENSBTAG00000007616; -.
DR VGNC; VGNC:110069; TMED6.
DR eggNOG; KOG3287; Eukaryota.
DR GeneTree; ENSGT00390000010961; -.
DR HOGENOM; CLU_066963_5_1_1; -.
DR InParanoid; Q0VCA9; -.
DR OMA; WHFAHQG; -.
DR TreeFam; TF313000; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000007616; Expressed in caput epididymis and 103 other cell types or tissues.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF45; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..240
FT /note="Transmembrane emp24 domain-containing protein 6"
FT /id="PRO_0000283034"
FT TOPO_DOM 22..200
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 53..138
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 27850 MW; 66F038D66E2E1872 CRC64;
MFPLLFVAGL VVLNLVSSAR SQKTEPLSGT GDQSLFRGAD QHDFAIVIPP GGTECFWQFA
HQTGYFYFSY EVQRTIGMSH DRHVAATAHT PQGFLIETSK NVRGQINFST HETGFYQLCL
ANQQNRFASV QVYLNFGVFY EGPEMDHKEN ERKQLNDTLD AIEESTRKVH YNIFHMWRHY
NFARMRKTAD FFLLQSNYNY VNWWSTAQSL VIVLSGILQL YFLKRLFNTP MTTETQKPRC
//
