ID TMM11_BOVIN Reviewed; 192 AA.
AC A5D7N3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Transmembrane protein 11, mitochondrial;
GN Name=TMEM11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in mitochondrial morphogenesis.
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26
CC and QIL1/MIC13. This complex was also known under the names MINOS or
CC MitOS complex. The MICOS complex associates with mitochondrial outer
CC membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner
CC membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P17152}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SIMILARITY: Belongs to the TMEM11 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC140623; AAI40624.1; -; mRNA.
DR RefSeq; NP_001091467.1; NM_001097998.2.
DR AlphaFoldDB; A5D7N3; -.
DR STRING; 9913.ENSBTAP00000074000; -.
DR PaxDb; 9913-ENSBTAP00000013971; -.
DR Ensembl; ENSBTAT00000013971.4; ENSBTAP00000013971.3; ENSBTAG00000010566.4.
DR GeneID; 508598; -.
DR KEGG; bta:508598; -.
DR CTD; 8834; -.
DR VEuPathDB; HostDB:ENSBTAG00000010566; -.
DR VGNC; VGNC:35950; TMEM11.
DR eggNOG; ENOG502QUAI; Eukaryota.
DR GeneTree; ENSGT00390000006617; -.
DR HOGENOM; CLU_095460_0_0_1; -.
DR InParanoid; A5D7N3; -.
DR OMA; TVSWQFD; -.
DR OrthoDB; 5296105at2759; -.
DR TreeFam; TF324685; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000010566; Expressed in laryngeal cartilage and 106 other cell types or tissues.
DR ExpressionAtlas; A5D7N3; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR InterPro; IPR026120; TMEM11.
DR PANTHER; PTHR15099; PROTEIN PM1; 1.
DR PANTHER; PTHR15099:SF2; TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL; 1.
DR Pfam; PF14972; Mito_morph_reg; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..192
FT /note="Transmembrane protein 11, mitochondrial"
FT /id="PRO_0000367036"
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 192 AA; 21479 MW; 289C0D6BBA5D44BB CRC64;
MAAWGRRRLG PGSGGGGARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE QALEAQYKYI
VIEPTRIGDE TARWITVGNC LHKTTVLAGT ACLFTPLALP LDYSHYISLP AGVLSLACCT
LYGISWQFDP CCKYQVEYDA YRLSRLPLHT LTSSTPVVLV RKDDLHRKRL HNTIALAALV
YCVKKIYELC AV
//
