ID TOLB_SALTY Reviewed; 430 AA.
AC Q8ZQT5;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=STM0748;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. TolB occupies a key intermediary
CC position in the Tol-Pal system because it communicates directly with
CC both membrane-embedded components, Pal in the outer membrane and TolA
CC in the inner membrane. {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AE006468; AAL19692.1; -; Genomic_DNA.
DR RefSeq; NP_459733.1; NC_003197.2.
DR RefSeq; WP_001562341.1; NC_003197.2.
DR PDB; 6PNV; X-ray; 1.42 A; A=23-430.
DR PDBsum; 6PNV; -.
DR AlphaFoldDB; Q8ZQT5; -.
DR SMR; Q8ZQT5; -.
DR STRING; 99287.STM0748; -.
DR PaxDb; 99287-STM0748; -.
DR GeneID; 1252268; -.
DR KEGG; stm:STM0748; -.
DR PATRIC; fig|99287.12.peg.784; -.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; VREPSWG; -.
DR PhylomeDB; Q8ZQT5; -.
DR BioCyc; SENT99287:STM0748-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.40.50.10070; TolB, N-terminal domain; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR InterPro; IPR007195; TolB_N.
DR NCBIfam; TIGR02800; propeller_TolB; 1.
DR PANTHER; PTHR42972; TOL-PAL SYSTEM PROTEIN TOLB; 1.
DR PANTHER; PTHR42972:SF8; TOL-PAL SYSTEM PROTEIN TOLB; 1.
DR Pfam; PF07676; PD40; 4.
DR Pfam; PF04052; TolB_N; 1.
DR SUPFAM; SSF52964; TolB, N-terminal domain; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Periplasm; Reference proteome;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 22..430
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000034685"
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 46..49
FT /evidence="ECO:0007829|PDB:6PNV"
FT HELIX 54..64
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 67..70
FT /evidence="ECO:0007829|PDB:6PNV"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:6PNV"
FT HELIX 88..92
FT /evidence="ECO:0007829|PDB:6PNV"
FT TURN 93..95
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 98..106
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 112..120
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 122..124
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 128..136
FT /evidence="ECO:0007829|PDB:6PNV"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:6PNV"
FT HELIX 141..157
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 166..172
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 180..186
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 193..200
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 202..207
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 211..218
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 225..230
FT /evidence="ECO:0007829|PDB:6PNV"
FT TURN 231..233
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 236..240
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 246..251
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 255..262
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 269..274
FT /evidence="ECO:0007829|PDB:6PNV"
FT TURN 275..277
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 280..282
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 286..288
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 290..295
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 299..306
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 313..318
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 330..339
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 343..352
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 355..362
FT /evidence="ECO:0007829|PDB:6PNV"
FT TURN 363..365
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 368..370
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 374..382
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 386..394
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 399..405
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 411..414
FT /evidence="ECO:0007829|PDB:6PNV"
FT STRAND 419..426
FT /evidence="ECO:0007829|PDB:6PNV"
SQ SEQUENCE 430 AA; 46149 MW; 2B31AB061FFFCE27 CRC64;
MKQALRVAFG FLMLWAAVLH AEVRIEITQG VDSARPIGVV PFKWAGPGAA PEDIGGIVAA
DLRNSGKFNP LDRSRLPQQP ATAQEVQPTA WSALGIDAVV VGQVTPNPDG SYNVAYQLVD
TGGAPGTVLA QNSYKVNKQW LRYAGHTASD EVFEKLTGIK GAFRTRIAYV VQTNGGQFPY
ELRVSDYDGY NQFVVHRSPQ PLMSPAWSPD GSKLAYVTFE SGRSALVIQT LANGAVRQVA
SFPRHNGAPA FSPDGTKLAF ALSKTGSLNL YVMDLASGQI RQITDGRSNN TEPTWFPDSQ
TLAFTSDQAG RPQVYKMNIN GGAAQRITWE GSQNQDADVS SDGKFMVMVS SNNGQQHIAK
QDLVTGGVQV LSSTFLDETP SLAPNGTMVI YSSSQGMGSV LNLVSTDGRF KARLPATDGQ
VKSPAWSPYL
//
