ID TPS11_RICCO Reviewed; 572 AA.
AC B9RHP7;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Probable terpene synthase 11;
DE Short=RcSeTPS11;
DE EC=4.2.3.-;
GN Name=TPS11; ORFNames=RCOM_1764780;
OS Ricinus communis (Castor bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC Ricinus.
OX NCBI_TaxID=3988;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Hale;
RX PubMed=20729833; DOI=10.1038/nbt.1674;
RA Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA Rabinowicz P.D.;
RT "Draft genome sequence of the oilseed species Ricinus communis.";
RL Nat. Biotechnol. 28:951-956(2010).
RN [2]
RP GENE NAME.
RX PubMed=22459969; DOI=10.1016/j.phytochem.2012.02.022;
RA Xie X., Kirby J., Keasling J.D.;
RT "Functional characterization of four sesquiterpene synthases from Ricinus
RT communis (castor bean).";
RL Phytochemistry 78:20-28(2012).
CC -!- FUNCTION: Probable sesquiterpene synthase. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
CC -!- DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for
CC the catalytic activity, presumably through binding to Mg(2+).
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Does not produce any detectable product when tested in
CC vitro. {ECO:0000305|PubMed:22459969}.
CC -!- SIMILARITY: Belongs to the terpene synthase family. {ECO:0000305}.
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DR EMBL; EQ973780; EEF49134.1; -; Genomic_DNA.
DR AlphaFoldDB; B9RHP7; -.
DR SMR; B9RHP7; -.
DR STRING; 3988.B9RHP7; -.
DR eggNOG; ENOG502QW72; Eukaryota.
DR InParanoid; B9RHP7; -.
DR OrthoDB; 532254at2759; -.
DR Proteomes; UP000008311; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR GO; GO:0120251; P:hydrocarbon biosynthetic process; IEA:UniProt.
DR CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR Gene3D; 1.50.10.130; Terpene synthase, N-terminal domain; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR034741; Terpene_cyclase-like_1_C.
DR InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR InterPro; IPR001906; Terpene_synth_N.
DR InterPro; IPR036965; Terpene_synth_N_sf.
DR InterPro; IPR005630; Terpene_synthase_metal-bd.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR31225; OS04G0344100 PROTEIN-RELATED; 1.
DR PANTHER; PTHR31225:SF137; TERPENE SYNTHASE 11-RELATED; 1.
DR Pfam; PF01397; Terpene_synth; 1.
DR Pfam; PF03936; Terpene_synth_C; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01019; Terpene_Cyclase_Like_1_C_Termi; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
PE 3: Inferred from homology;
KW Lyase; Magnesium; Metal-binding; Reference proteome.
FT CHAIN 1..572
FT /note="Probable terpene synthase 11"
FT /id="PRO_0000422209"
FT MOTIF 317..321
FT /note="DDXXD motif"
FT BINDING 317
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 317
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 321
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 321
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 469
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 572 AA; 65426 MW; 73CC61A0201B8606 CRC64;
MSMIGTKSFF ISSSPKVPVG ISWGPSSYRT NSSLSVRSPT LTCSISTISQ PTRKEPATTK
PEIMEELHEG TRKELLTSSS PIATMKLIDS IQRLGVGYYF EEEINTLLDR FLDLETTEDL
LATALRFRLL RDNCFPAHSD VFGKFMNKDG KFKESLRKDV WGLLSLYEAS YLGTKDEVEL
VEAMEFTKTC LEEQSIPLMA HKLSRHVSQA LDLPRHLRMP RLEARNYIHE YSLESNNSPP
LLELAKLEFN AVQSLHQKEL IEIVRWWKQL GLVDKLGFAR DRPLECYLWT VGIFPEPYNS
TCRIELTKTI AILLVIDDIF DTYGSLPDLI LFTEAVRRWD LNAMESLPEY MKICYMALYN
TTNDIGFMIL KRHGLSIVPH LKRTWIDMFE AFLTEAKWFN SGYVPTLEEY LDNGVTTGGT
YMALVHSFFL MGQGVNKETV TMMEPYPDLF SLSGRILRLW DDLGTAREEQ ERGDVACSIE
CLMREKRISC DDEGRKQVRQ LIRSLWTELN GELIAPSAMP LSIINASLNL ARTAQVVYQH
GDDKKGSSVD NQVQALIYIP ISFPKRRDLK LL
//
