ID TR112_DICDI Reviewed; 128 AA.
AC Q54N57;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Multifunctional methyltransferase subunit TRM112-like protein;
DE AltName: Full=tRNA methyltransferase 112 homolog;
GN ORFNames=DDB_G0285489;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as an activator of both RNA and protein
CC methyltransferases. {ECO:0000250|UniProtKB:Q9UI30}.
CC -!- SIMILARITY: Belongs to the TRM112 family. {ECO:0000305}.
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DR EMBL; AAFI02000079; EAL64582.1; -; Genomic_DNA.
DR RefSeq; XP_638086.1; XM_632994.1.
DR AlphaFoldDB; Q54N57; -.
DR SMR; Q54N57; -.
DR STRING; 44689.Q54N57; -.
DR PaxDb; 44689-DDB0186528; -.
DR EnsemblProtists; EAL64582; EAL64582; DDB_G0285489.
DR GeneID; 8625132; -.
DR KEGG; ddi:DDB_G0285489; -.
DR dictyBase; DDB_G0285489; -.
DR eggNOG; KOG1088; Eukaryota.
DR HOGENOM; CLU_086140_2_1_1; -.
DR InParanoid; Q54N57; -.
DR OMA; GELVCNN; -.
DR PhylomeDB; Q54N57; -.
DR Reactome; R-DDI-156581; Methylation.
DR Reactome; R-DDI-72764; Eukaryotic Translation Termination.
DR PRO; PR:Q54N57; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0070476; P:rRNA (guanine-N7)-methylation; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR Gene3D; 2.20.25.10; -; 1.
DR InterPro; IPR039127; Trm112.
DR InterPro; IPR005651; Trm112-like.
DR PANTHER; PTHR12773:SF0; MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN; 1.
DR PANTHER; PTHR12773; UPF0315 PROTEIN-RELATED; 1.
DR Pfam; PF03966; Trm112p; 1.
DR SUPFAM; SSF158997; Trm112p-like; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..128
FT /note="Multifunctional methyltransferase subunit TRM112-
FT like protein"
FT /id="PRO_0000331129"
FT DOMAIN 2..111
FT /note="TRM112"
SQ SEQUENCE 128 AA; 14923 MW; 6AE602EFA45899DC CRC64;
MKILTHNMMA CTKKQCMGKG FPLKVESTEQ IVLEQEFNYE FTKNIYPKLD WLGIAEISIK
FNIPIQLDTT KHSLEDEEFL KTLHNLLCNL KVITGSLTCP NCQRVYPIDK GIPNMLLRED
EIYQEIKE
//
