ID TR117_RAT Reviewed; 318 AA.
AC Q675B8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=Taste receptor type 2 member 117;
DE Short=T2R117;
DE AltName: Full=Taste receptor type 2 member 39;
DE Short=T2R39;
GN Name=Tas2r117 {ECO:0000250|UniProtKB:Q7M715}; Synonyms=T2r39;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAS57910.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAS57910.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY486339; AAS57910.1; -; Genomic_DNA.
DR RefSeq; NP_001160154.1; NM_001166682.1.
DR AlphaFoldDB; Q675B8; -.
DR SMR; Q675B8; -.
DR STRING; 10116.ENSRNOP00000063238; -.
DR GlyCosmos; Q675B8; 1 site, No reported glycans.
DR GlyGen; Q675B8; 1 site.
DR PaxDb; 10116-ENSRNOP00000063238; -.
DR Ensembl; ENSRNOT00055046127; ENSRNOP00055037854; ENSRNOG00055026714.
DR Ensembl; ENSRNOT00060034033; ENSRNOP00060027875; ENSRNOG00060019724.
DR Ensembl; ENSRNOT00065019616; ENSRNOP00065015047; ENSRNOG00065012069.
DR GeneID; 100310880; -.
DR KEGG; rno:100310880; -.
DR UCSC; RGD:2314258; rat.
DR AGR; RGD:2314258; -.
DR CTD; 353166; -.
DR RGD; 2314258; Tas2r117.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q675B8; -.
DR OrthoDB; 4845723at2759; -.
DR PhylomeDB; Q675B8; -.
DR TreeFam; TF335891; -.
DR PRO; PR:Q675B8; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR CDD; cd15019; 7tm_TAS2R14-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF61; TASTE RECEPTOR TYPE 2 MEMBER 117; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..318
FT /note="Taste receptor type 2 member 117"
FT /id="PRO_0000248478"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 318 AA; 37090 MW; 1B1E758EDDEA9966 CRC64;
MQHNLKTIFV ISHSTLTIIL FTELVTGIIG NGFMALVHCM DWLRRKKISL VNQILTALAI
SRIFQLCLLF ISLVISFSYP DLTTTSLIKV TCNLWIIVNH FNIWLATCLG IFYFLKISNF
SNSLFLYLKW RVEKVVLVTL LVSLVLLTLN SLLINLEINI CINEYQRNIT YSFNSYYHAN
CHRQMLSLHI IFLSVPFVLS LSTFLLLIFS LGTHHKKMQQ HVQGRRDAST MAHFKALQTV
IAFLLLYSIF ILSVLVQIWK YELLKKNLFI LFCQVAYVAF PSFHSYILIL GDMKMRQACL
SVLWWQKFRK NYVEPLDL
//
