ID TR136_RAT Reviewed; 330 AA.
AC Q675B7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Taste receptor type 2 member 136;
DE Short=T2R136;
DE AltName: Full=Taste receptor type 2 member 40;
DE Short=T2R40;
GN Name=Tas2r136 {ECO:0000250|UniProtKB:Q7TQA8}; Synonyms=Tas2r40;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAS57911.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAS57911.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY486340; AAS57911.1; -; Genomic_DNA.
DR RefSeq; NP_001160150.1; NM_001166678.1.
DR AlphaFoldDB; Q675B7; -.
DR SMR; Q675B7; -.
DR STRING; 10116.ENSRNOP00000048980; -.
DR GlyCosmos; Q675B7; 2 sites, No reported glycans.
DR GlyGen; Q675B7; 2 sites.
DR PhosphoSitePlus; Q675B7; -.
DR PaxDb; 10116-ENSRNOP00000048980; -.
DR Ensembl; ENSRNOT00000052034.2; ENSRNOP00000048980.1; ENSRNOG00000029561.2.
DR Ensembl; ENSRNOT00055046118; ENSRNOP00055037845; ENSRNOG00055026709.
DR Ensembl; ENSRNOT00060034025; ENSRNOP00060027867; ENSRNOG00060019720.
DR Ensembl; ENSRNOT00065019612; ENSRNOP00065015043; ENSRNOG00065012067.
DR GeneID; 100310876; -.
DR KEGG; rno:100310876; -.
DR UCSC; RGD:2314262; rat.
DR AGR; RGD:2314262; -.
DR CTD; 353165; -.
DR RGD; 2314262; Tas2r136.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q675B7; -.
DR OMA; YERNITQ; -.
DR OrthoDB; 5306466at2759; -.
DR PhylomeDB; Q675B7; -.
DR TreeFam; TF335891; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q675B7; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR CDD; cd15027; 7tm_TAS2R43-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF81; TASTE RECEPTOR TYPE 2 MEMBER 136; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..330
FT /note="Taste receptor type 2 member 136"
FT /id="PRO_0000247663"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..122
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 330 AA; 37358 MW; A002D1AC183CDD3F CRC64;
MKSQPVTQEL HFIFPLFKTI SSDIMSFLVS IAGIAMLAQI VLGTFANVFI VLVTCTDCIR
RRKLFLADGI LTSLAFCRIG MLWVILISWC SIVFHQALSL QVRFSICVGW AVTNHFNMWL
ATILSILYLL KIGNFSNLIF LGLKRKIKSV FIVVLLASLV LLFPNLITVT VCETVQANGY
RGNLTGKTKR TYFMNLTAMI SFTLDNIISF TISMVCFLLL IYSLCKHLRT MRLYGKGPHN
PSASAHIKAL QAVISFLLLF SMFILSLIIS GYNYMKPLNE PVHLICQLIG TLYPSSHSYV
LLWGNRRIKL AFVLAMVQVR ARLWLKEEKP
//
