ID TRPF_HALVD Reviewed; 221 AA.
AC P52563; D4GT39;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE Short=PRAI;
DE EC=5.3.1.24;
GN Name=trpF; OrderedLocusNames=HVO_2455;
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DS2 / DSM 5716 / WFD11;
RX PubMed=1537810; DOI=10.1128/jb.174.5.1694-1697.1992;
RA Lam W.L., Logan S.M., Doolittle W.F.;
RT "Genes for tryptophan biosynthesis in the halophilic archaebacterium
RT Haloferax volcanii: the trpDFEG cluster.";
RL J. Bacteriol. 174:1694-1697(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC B-1768 / DS2;
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR EMBL; M83788; AAA73176.1; -; Genomic_DNA.
DR EMBL; CP001956; ADE04719.1; -; Genomic_DNA.
DR RefSeq; WP_004042369.1; NZ_AOHU01000044.1.
DR AlphaFoldDB; P52563; -.
DR SMR; P52563; -.
DR STRING; 309800.HVO_2455; -.
DR PaxDb; 309800-C498_07575; -.
DR EnsemblBacteria; ADE04719; ADE04719; HVO_2455.
DR GeneID; 8924041; -.
DR KEGG; hvo:HVO_2455; -.
DR eggNOG; arCOG01983; Archaea.
DR HOGENOM; CLU_076364_2_1_2; -.
DR OrthoDB; 27513at2157; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000008243; Chromosome.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR PANTHER; PTHR42894:SF1; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..221
FT /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT /id="PRO_0000154401"
SQ SEQUENCE 221 AA; 22634 MW; 396453808C71FBAD CRC64;
MTRVKVCGVT DETDLAAVDA AGADAVGAIC DVPVDTPREI PRERARELFA AAPPFLTTTL
VTMPDSVDHA RDLAREVGPD VLQLHGDFAA DDLDSLRATG VGVVPVVDAT DLARARDLAP
VVDAILVDTP SDSGAGGTGE THDWDASRDL VAAVDAPVIL AGGLTPDNVV EAVRTVEPYG
VDVASGVEAS GGVKDHDAVR AFVAAAKTAR GAVDDHEEVV A
//
