ID TSN16_HUMAN Reviewed; 245 AA.
AC Q9UKR8; K7EN22; K7EPD8; Q8N6J7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 143.
DE RecName: Full=Tetraspanin-16;
DE Short=Tspan-16;
DE AltName: Full=Tetraspanin TM4-B;
DE AltName: Full=Transmembrane 4 superfamily member 16;
GN Name=TSPAN16; Synonyms=TM4SF16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10500248; DOI=10.1016/s0167-4781(99)00116-5;
RA Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.;
RT "The molecular characterisation of a novel tetraspanin protein, TM4-B.";
RL Biochim. Biophys. Acta 1447:93-99(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9UKR8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UKR8-2; Sequence=VSP_056726;
CC Name=3;
CC IsoId=Q9UKR8-3; Sequence=VSP_056723, VSP_056726;
CC Name=4;
CC IsoId=Q9UKR8-4; Sequence=VSP_056724, VSP_056725;
CC -!- TISSUE SPECIFICITY: Broadly expressed in most human tissues and cell
CC lines including neural and bone marrow derived tissues.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF133424; AAF08363.1; -; mRNA.
DR EMBL; AC011472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC098777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029908; AAH29908.1; -; mRNA.
DR CCDS; CCDS12256.1; -. [Q9UKR8-1]
DR CCDS; CCDS62549.1; -. [Q9UKR8-2]
DR CCDS; CCDS62550.1; -. [Q9UKR8-3]
DR RefSeq; NP_001269438.1; NM_001282509.1. [Q9UKR8-2]
DR RefSeq; NP_001269439.1; NM_001282510.1. [Q9UKR8-3]
DR RefSeq; NP_036598.1; NM_012466.3. [Q9UKR8-1]
DR AlphaFoldDB; Q9UKR8; -.
DR SMR; Q9UKR8; -.
DR BioGRID; 117729; 23.
DR STRING; 9606.ENSP00000319486; -.
DR BioMuta; TSPAN16; -.
DR DMDM; 11135364; -.
DR jPOST; Q9UKR8; -.
DR MassIVE; Q9UKR8; -.
DR PaxDb; 9606-ENSP00000319486; -.
DR PeptideAtlas; Q9UKR8; -.
DR ProteomicsDB; 72182; -.
DR ProteomicsDB; 84842; -. [Q9UKR8-1]
DR Antibodypedia; 52080; 77 antibodies from 10 providers.
DR DNASU; 26526; -.
DR Ensembl; ENST00000316737.5; ENSP00000319486.1; ENSG00000130167.14. [Q9UKR8-1]
DR Ensembl; ENST00000337994.5; ENSP00000338759.5; ENSG00000130167.14. [Q9UKR8-4]
DR Ensembl; ENST00000590327.6; ENSP00000467341.1; ENSG00000130167.14. [Q9UKR8-2]
DR Ensembl; ENST00000592955.5; ENSP00000466751.1; ENSG00000130167.14. [Q9UKR8-3]
DR Ensembl; ENST00000621731.4; ENSP00000480759.1; ENSG00000130167.14. [Q9UKR8-4]
DR GeneID; 26526; -.
DR KEGG; hsa:26526; -.
DR MANE-Select; ENST00000590327.6; ENSP00000467341.1; NM_001282509.2; NP_001269438.1. [Q9UKR8-2]
DR UCSC; uc002mqv.3; human. [Q9UKR8-1]
DR AGR; HGNC:30725; -.
DR CTD; 26526; -.
DR DisGeNET; 26526; -.
DR GeneCards; TSPAN16; -.
DR HGNC; HGNC:30725; TSPAN16.
DR HPA; ENSG00000130167; Tissue enriched (testis).
DR MIM; 617580; gene.
DR neXtProt; NX_Q9UKR8; -.
DR OpenTargets; ENSG00000130167; -.
DR PharmGKB; PA134989909; -.
DR VEuPathDB; HostDB:ENSG00000130167; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00510000049338; -.
DR HOGENOM; CLU_055524_7_1_1; -.
DR InParanoid; Q9UKR8; -.
DR OMA; HVGCLCL; -.
DR OrthoDB; 4595051at2759; -.
DR PhylomeDB; Q9UKR8; -.
DR TreeFam; TF316345; -.
DR PathwayCommons; Q9UKR8; -.
DR BioGRID-ORCS; 26526; 21 hits in 1141 CRISPR screens.
DR ChiTaRS; TSPAN16; human.
DR GenomeRNAi; 26526; -.
DR Pharos; Q9UKR8; Tbio.
DR PRO; PR:Q9UKR8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UKR8; Protein.
DR Bgee; ENSG00000130167; Expressed in sperm and 102 other cell types or tissues.
DR ExpressionAtlas; Q9UKR8; baseline and differential.
DR Genevisible; Q9UKR8; HS.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR CDD; cd03156; uroplakin_I_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF455; TETRASPANIN-16; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..245
FT /note="Tetraspanin-16"
FT /id="PRO_0000219264"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 90..114
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_056723"
FT VAR_SEQ 151..160
FT /note="LKCCGVNNYT -> GLSKYFFSSL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056724"
FT VAR_SEQ 161..245
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056725"
FT VAR_SEQ 230..245
FT /note="RWGSRYVAQAGLELLA -> LPGILATLLLFIKLG (in isoform 2
FT and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_056726"
FT VARIANT 53
FT /note="Y -> D (in dbSNP:rs34162761)"
FT /id="VAR_052329"
FT VARIANT 55
FT /note="L -> P (in dbSNP:rs17001344)"
FT /id="VAR_052330"
FT VARIANT 233
FT /note="S -> C (in dbSNP:rs318687)"
FT /id="VAR_052331"
SQ SEQUENCE 245 AA; 26266 MW; 064CDE593AB2B48C CRC64;
MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS SAYLLHVGNL
CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM EVTAATVVLL FFPIVGDVAL
EHTFVTLRKN YRGYNEPDDY STQWNLVMEK LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC
KSIGSVSCDG RDVSPNVIHQ KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG
LELLA
//
