ID TSN1_RAT Reviewed; 241 AA.
AC Q6AYR9;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 24-JAN-2024, entry version 119.
DE RecName: Full=Tetraspanin-1;
DE Short=Tspan-1;
GN Name=Tspan1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; BC078938; AAH78938.1; -; mRNA.
DR RefSeq; NP_001004236.1; NM_001004236.1.
DR RefSeq; XP_006238701.1; XM_006238639.2.
DR RefSeq; XP_017448763.1; XM_017593274.1.
DR AlphaFoldDB; Q6AYR9; -.
DR SMR; Q6AYR9; -.
DR STRING; 10116.ENSRNOP00000072392; -.
DR GlyCosmos; Q6AYR9; 1 site, No reported glycans.
DR GlyGen; Q6AYR9; 1 site.
DR PhosphoSitePlus; Q6AYR9; -.
DR PaxDb; 10116-ENSRNOP00000018766; -.
DR Ensembl; ENSRNOT00000018766.5; ENSRNOP00000018766.3; ENSRNOG00000023320.5.
DR Ensembl; ENSRNOT00055022379; ENSRNOP00055018155; ENSRNOG00055013073.
DR Ensembl; ENSRNOT00060048682; ENSRNOP00060040595; ENSRNOG00060028016.
DR Ensembl; ENSRNOT00065026923; ENSRNOP00065021165; ENSRNOG00065016169.
DR GeneID; 298436; -.
DR KEGG; rno:298436; -.
DR UCSC; RGD:1303308; rat.
DR AGR; RGD:1303308; -.
DR CTD; 10103; -.
DR RGD; 1303308; Tspan1.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000158851; -.
DR InParanoid; Q6AYR9; -.
DR OMA; CYGAHTE; -.
DR OrthoDB; 2966000at2759; -.
DR PhylomeDB; Q6AYR9; -.
DR TreeFam; TF352892; -.
DR PRO; PR:Q6AYR9; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000023320; Expressed in stomach and 18 other cell types or tissues.
DR Genevisible; Q6AYR9; RN.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0031982; C:vesicle; ISO:RGD.
DR GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR CDD; cd03156; uroplakin_I_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF216; TETRASPANIN-1; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..241
FT /note="Tetraspanin-1"
FT /id="PRO_0000382892"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 241 AA; 26453 MW; 9118E865464D1A70 CRC64;
MQCFKFIKVM MILFNLLIFL CGAALLAVGI WVSVDGTSFL KAFGSLSSSA MQFVNVGYFL
IAAGAVLFIL GFLGCYGAHS ENKCVLMMFF SILLIIFIAE IAGAVVALVY TTMAEQFLTF
LVVPAIEKDY GYQTEFTQVW NSTMEGLHCC GFNNYTDFNS SRFVKENKVF PPFCCANNTD
SHTVEPCTED KAKSMNVQGC FKQILQKIRT NAVTVGGVAV GVAALELAAM VVSMYLYCNL
K
//
