ID TTC30_ANOGA Reviewed; 654 AA.
AC Q7PRA4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 24-JAN-2024, entry version 113.
DE RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE Short=TPR repeat protein 30 homolog;
GN ORFNames=AGAP002877;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin in sensory
CC cilia. Plays a role in anterograde intraflagellar transport (IFT), the
CC process by which cilia precursors are transported from the base of the
CC cilium to the site of their incorporation at the tip. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008859; EAA07585.3; -; Genomic_DNA.
DR RefSeq; XP_312036.2; XM_312036.2.
DR AlphaFoldDB; Q7PRA4; -.
DR SMR; Q7PRA4; -.
DR STRING; 7165.Q7PRA4; -.
DR PaxDb; 7165-AGAP002877-PA; -.
DR EnsemblMetazoa; AGAP002877-RA; AGAP002877-PA; AGAP002877.
DR GeneID; 1273090; -.
DR KEGG; aga:AgaP_AGAP002877; -.
DR CTD; 1273090; -.
DR VEuPathDB; VectorBase:AGAP002877; -.
DR eggNOG; KOG4340; Eukaryota.
DR HOGENOM; CLU_023760_0_0_1; -.
DR InParanoid; Q7PRA4; -.
DR OMA; CCKHELY; -.
DR OrthoDB; 5477075at2759; -.
DR PhylomeDB; Q7PRA4; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF13432; TPR_16; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..654
FT /note="Tetratricopeptide repeat protein 30 homolog"
FT /id="PRO_0000333212"
FT REPEAT 10..43
FT /note="TPR 1"
FT REPEAT 44..76
FT /note="TPR 2"
FT REPEAT 145..178
FT /note="TPR 3"
FT REPEAT 180..212
FT /note="TPR 4"
FT REPEAT 393..426
FT /note="TPR 5"
FT REPEAT 452..485
FT /note="TPR 6"
FT REPEAT 535..568
FT /note="TPR 7"
SQ SEQUENCE 654 AA; 72382 MW; C6895B318569F30F CRC64;
MFSQNMIIRD GEYTKTIYTM IKEERFQDAI NTLNTIPESS TTRAGLSLLG HCYYQTQDFI
EAANCYEHLL NLVPDVQEYR LYYAQSLFQA GLFEEAQKII ATGLDSPELK EKVLQLQSAI
AYGNEDYTAA QSLLLQRQDG NGQEASTKND EGCLLYQANM YEDALQRYVS ALQAGGFNPH
VAYNAALCHY RRKENSQALN YIAEIVERGI RNHPELGVGA QAETEGGARS VGNPPALAAS
GLAQAFNLKA AIEYQEGNAD GAREALTDLP PRSEPELDPV TLHNMALTDP TGGGAGLRRL
AFLLELGPPA CPPETFANLL LLCCKHEMYD TAADILAEHT HLTYKYLSPY LYDLLDALIT
AQSTPEEAEQ KLGTLASSIG GRLRALAAKV QECRSATDQN ALRMALREYE GALESYLPVA
MARAWIPWRM DDFQGAEREF RASAEFCSET PSWRLHAAHV LFMRGDRYKE AAAFYEPIVR
QNYDDILSIP ASVLANLCVA YIMTSQNEEA EELMRKVERA EERKGNATGQ CLHLCIVNLV
IGTLYCAKNN YEFGLSRIAH ALDGGSGARL CADTWIHVKR CVLGLLTGMA KQTIVLPSIA
LQETLNFLRA CEAYGLTIPS VLTGPLEDSG EQPPTIGLEA RKLRALLLRL MEYK
//
